Roscoe O. Brady

Roscoe O. Brady (about 1970)

Roscoe Owen Brady (born October 11, 1923 in Philadelphia , Pennsylvania - † June 13, 2016 ) was an American biochemist and geneticist at the National Institute of Neurological Disorders and Stroke in Bethesda , Maryland .

Life

After attending Pennsylvania State University , Brady earned an MD from Harvard Medical School in 1947 with a medical degree. As a postdoctoral fellow , he worked in the Department of Biochemistry at the University of Pennsylvania School of Medicine , where he was also an intern in internal medicine . After two and a half years of military service with the US Naval Medical Corps , Brady joined the United States' National Institutes of Health (NIH) in 1952 . Most recently, he was Head of Developmental and Metabolic Neurology at the National Institute of Neurological Disorders and Stroke , an NIH facility based in Bethesda , Maryland . Since 2006, emeritus , Brady died in June 2016th

Act

Brady was essential for understanding the molecular mechanisms of Sphingolipidoses ( sphingolipid - storage diseases contribute). He discovered various enzyme defects in lipid metabolism as the respective cause of, for example, Gaucher's disease , Niemann-Pick disease , Fabry's disease or Tay-Sachs syndrome . Brady developed procedures for human genetic counseling and was able to establish successful enzyme replacement therapies for previously incurable diseases. Brady encouraged the successful establishment of numerous biotechnological companies that manufacture the corresponding therapeutic substances.

More recent work deals with the genetic causes of other neurodegenerative diseases such as mucolipidosis IV , leukodystrophies of previously unknown etiology and new forms of peripheral neuropathy . The previously undetected diseases Childhood Ataxia with Central Nervous System Hypomyelination (CACH) and Ovarioleukodystrophy were identified. New methods to determine the effectiveness of enzyme therapy and new methods of gene therapy for hereditary neurological metabolic diseases have been developed.

Awards (selection)

• 1973 Gairdner Foundation International Award
• 1975 membership in the National Academy of Sciences
• 1982 Albert Lasker Award for Clinical Medical Research
• 1982 Passano Award
• 1991 Jessie Stevenson Kovalenko Medal
• 1992 Warren Alpert Foundation Prize
• 2007 National Medal of Technology
• 2010 Pollin Pediatric Research Prize

literature

• Biography of Dr. Roscoe O. Brady. In: Glycoconjugate Journal (2004) Volume 20, No. 5, P. 289 doi: 10.1023 / B: GLYC.0000033655.64376.28

Web links

Commons : Roscoe O. Brady  - Collection of Images, Videos, and Audio Files

• Roscoe O. Brady, MD, Senior Investigator at the National Institutes of Health (nih.gov); Retrieved March 13, 2012

Individual evidence

1. ↑ Malika Ammam: Dr. Roscoe Brady, Pioneer Scientist in Gaucher Disease, Dies at 92. In: Gaucher Disease News. June 17, 2016, accessed February 14, 2017 . 
2. ↑ Roscoe O. Brady, MD at the Gairdner Foundation (gairdner.org); Retrieved December 7, 2012.
3. ↑ Roscoe Brady at the Lasker Foundation (laskerfoundation.org); Retrieved March 13, 2012.
4. ^ The Passano Award 1945 to 2011 at the Passano Foundation (passanofoundation.org); Retrieved October 2, 2012.
5. ^ Jessie Stevenson Kovalenko Medal at the National Academy of Sciences (nasonline.org); Retrieved March 13, 2012.
6. ↑ 2007 Laureates at uspto.gov; Retrieved March 13, 2012.
7. ^ Pollin Pediatric Research Prize Awarded for Discovering Molecular and Biochemical Basis of Genetic Diseases at NewYork-Presbyterian Hospital (nyp.org); Retrieved March 14, 2012.