The Rous sarcoma virus ( RSV ) is an RNA virus from the retrovirus family ( Retroviridae ). It was first described by Peyton Rous in 1911 when he succeeded in injecting filtered, cell-free extract from chicken tumors into healthy chickens, thereby inducing the same tumors in them. The tumors consisted of connective tissue and were therefore referred to as sarcomas . In 1966, Rous received the Nobel Prize in Physiology or Medicine for his discovery . After the avian leukosis virus, RSV was only the second retrovirus whose transmission has ever been described.
The Rous sarcoma virus genome has LTRs that enable integration into the host genome.
literature
J. Svoboda: Rous sarcoma virus. , Intervirology, Vol. 26, 1986, pp. 1-60. PMID 2437068
WR Bryan: Biological studies on the Rous sarcoma virus. I. General introduction. II. Review of sources of experimental variation and of methods for their control. , J. Natl. Cancer Inst., Vol. 16, 1955, pp. 285-315. PMID 13243128
