Thimerfonat

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Structural formula
Structure of Thimerfonat
General
Surname Thimerfonat
other names
  • Timerfonat
  • Ethyl (4-sulfophenyl) sulfanyl mercury
  • Sodium timeronate (sodium salt)
  • Sodium thimerfonate (sodium salt)
Molecular formula C 8 H 10 HgO 3 S 2
External identifiers / databases
CAS number
  • 33305-56-5
  • 5964-24-9 (sodium salt)
PubChem 169497
Wikidata Q2421144
Drug information
Drug class

antiseptic

properties
Molar mass 418.88 g · mol -1
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary
06 - Toxic or very toxic 08 - Dangerous to health 09 - Dangerous for the environment

danger

H and P phrases H: 330-310-300-373-410
P: ?
Toxicological data

56 mg kg −1 ( LD 50 ,  mouse ,  iv )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Thimerfonat , also timerfonat , is an organic mercury compound and a benzenesulfonic acid that has been added to vaccines to keep them sterile since the 1930s . It was mostly used as sodium salt. However, organic compounds containing mercury are no longer used for human vaccines.

Thimerfonat was contained in many bacterial vaccines ( cholera , pneumococci ), in flu vaccines and also in vaccines against diphtheria . The WHO had once no objections to the application. Neither the EMA nor the Institute of Medicine saw any scientific evidence of a link between vaccinations and autism or other neurological disorders in children. The FDA endorsed this assessment.

Sodium timeronate is listed by the EU on the list of pharmaceutical substances that are duty-free .

See also

Individual evidence

  1. ↑ Entry on organic mercury compounds in the GESTIS substance database of the IFA , accessed on February 1, 2016 (JavaScript required)
  2. ↑ Not explicitly listed in Regulation (EC) No. 1272/2008 (CLP) , but with the specified labeling it falls under the group entry organic compounds of mercury with the exception of those specified elsewhere in this Annex in the Classification and Labeling Inventory of the European Chemicals Agency ( ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
  3. ↑ Entry on sodium thimerfonate in the ChemIDplus database of the United States National Library of Medicine (NLM)
  4. ↑ H. Spiess, U. Heininger: Impfkompendium . 6th edition. Thieme, Stuttgart 2005, ISBN 3-13-498906-9 , p. 62-63 .
  5. ↑ PEI vaccination and mercury / thiomersal - answers to critical questions. Retrieved July 31, 2018 .
  6. ↑ Avoxa ?? Mediengruppe Deutscher Apotheker GmbH: Pharmaceutical newspaper online: Medicinal and useful plants with skin problems. Retrieved July 31, 2018 .
  7. ↑ Influenza vaccines 97/98 in comparison - arznei telegram . ( arznei-telegramm.de [accessed on July 31, 2018]).
  8. ^ Muller: European Drug Index: European Drug Registrations . 4th edition. CRC Press, 1998, ISBN 978-3-7692-2114-5 (English, limited preview in Google Book Search [accessed July 31, 2018]).
  9. ↑ a b Burkhard Schneeweiß and Brigitten Keller-Stanislawski: Vaccine safety versus vaccine skepticism. Retrieved July 31, 2018 .
  10. ^ Center for Biologics Evaluation and Research: Vaccine Safety & Availability - Thimerosal and Vaccines. Retrieved July 31, 2018 .
  11. ↑ Regulation (EC) No. 578/2002 of the Commission of March 20, 2002 amending Annex I of Regulation (EEC) No. 2658/87 of the Council on the tariff and statistical nomenclature and the common customs tariff . In: Official Journal of the European Communities . L, No. 97, April 13, 2002, pp. 1-98.