Tobias Moser

from Wikipedia, the free encyclopedia
Tobias Moser (2018)

Tobias Moser (born March 24, 1968 in Görlitz ) is a German physician and neuroscientist.

life and career

Tobias Moser completed his medical studies in Leipzig and Jena / Erfurt with a doctorate as Dr. med. in 1995 onwards. This was followed by a postdoc with Erwin Neher at the Max Planck Institute for Biophysical Chemistry from 1994 to 1997. There he was a junior research group leader from 1997 to 2001 and at the same time affiliated with the Otorhinolaryngology of the Göttingen University Medical Center . He received his habilitation in 2003 , then W2 in 2005 and finally W3 in 2007 as Professor of Auditory Neuroscience at the Clinic for Otorhinolaryngology at the University Medical Center Göttingen. Since 2015 he has been director of the Institute for Auditory Neuroscience at the University Medical Center Göttingen. He is a founding member and board member of the Göttingen Graduate School for Neurosciences, Biophysics and Molecular Biosciences (GGNB).

Tobias Moser is married and has three children.

Scientific fields of work

Tobias Moser deals with issues of cellular and systemic neurosciences and sensory sciences, biophysics, optophysiology and neuroprosthetics, clinical audiology and otology.

He researched the physiology and anatomy of hair cell synapses and their malfunctions in diseases and did pioneering work. Moser developed optogenetic techniques that give hope for optical cochlear implants . Instead of using an electric current via relatively coarse electrodes, a light signal is used to stimulate the auditory nerves. Moser and colleagues (who worked with the cochlear implant manufacturer MED-EL) built a channel protein (channelrhodopsin 2) into the membranes of the auditory nerve in mice, using gene therapy techniques (virus vector), and stimulated this with light LED on.

He investigates the molecular and cellular causes of hearing loss and found, for example, that a rare form of congenital hearing loss is due to a defective or insufficient membrane protein (otoferlin). If there is a disorder, the signal transmission from the sensory cells of the ear to the auditory nerve no longer works well.

Awards and memberships

Tobias Moser received a scholarship from the German National Academic Foundation , won the 1996 PhD award from the Friedrich Schiller University in Jena , the Marius Tausk Award from the German Society for Endocrinology in 1996, the German Society for Audiology Award 2001 and the HFSP Young Investigator Grant Award and the Meyer-zum-Gottesberge-Preis of the German Society for Audiology in 2004, the Habilitation Prize of the University of Göttingen in 2005 and, in 2015, the Gottfried Wilhelm Leibniz Prize of the German Research Foundation . In 2015 he was elected a member of the Leopoldina . For 2017, Moser was awarded the Ernst Jung Prize and he received the Lower Saxony Science Prize .

Fonts (selection)

  • with D. Beutner: Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse, Proc. Nat. Acad. USA, Vol. 97, 2000, pp. 883-888
  • with Dirk Beutner, Thomas Voets, Erwin Neher: Calcium dependence of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse, Neuron, Volume 29, 2000, pp. 681-690
  • with Thomas Voets, Thomas Südhoff, Erwin Neher, Mathijs Verhage u. a .: Munc18-1 promotes large dense-core vesicle docking, Neuron, Volume 31, 2001, pp. 581-592
  • with Paul A. Fuchs, Elisabeth Glowatzki: The afferent synapse of cochlear hair cells, Current Opinion in Neurobiology, Volume 13, 2003, pp. 452-458
  • with A. Brandt, J. Strieesnig: CaV1. 3 channels are essential for development and presynaptic activity of cochlear inner hair cells, Journal of Neuroscience, Volume 23, 2003, pp. 10832-10840
  • with D. Khimich u. a .: Hair cell synaptic ribbons are essential for synchronous auditory signaling, Nature, Volume 434, 2005, pp. 889-894
  • with A. Brandt, D. Khimich: Few CaV1. 3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse, Journal of Neuroscience, Volume 25, 2005, pp. 11577-11585
  • with R. Nouvian, D. Beutner, T. Parsons: Structure and function of the hair cell ribbon synapse, Journal of membrane biology, Volume 209, 2006, pp. 153-165
  • with Isabelle Roux u. a .: Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse, Cell, Volume 127, 2006, pp. 277-289
  • with AC Meyer u. a .: Tuning of synapse number, structure and function in the cochlea, Nature Neuroscience , Volume 12, 2009, pp. 444-453
  • with Arnold Starr: Auditory neuropathy - neural and synaptic mechanisms, Nature Review Neurology, Volume 12, No. 3, 2016, pp. 135-149, PMID 26891769

Web links

Individual evidence

  1. ^ Lower Saxony Science Award 2017 (pdf), Lower Saxony Ministry of Culture
  2. ↑ Cochlear implants boosted by gene therapy plus tiny LEDs, New Scientist, July 7, 2016
  3. ↑ Too little Otoferlin makes hearing "tired" - even during exercise and fever , press release Uni Göttingen, December 22, 2016
  4. ↑ Member entry by Prof. Dr. Tobias Moser (with picture and CV) at the German Academy of Sciences Leopoldina
personal data
SURNAME Moser, Tobias
BRIEF DESCRIPTION German medic
DATE OF BIRTH March 24, 1968
PLACE OF BIRTH Goerlitz