VG (nerve agent)

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Structural formula
Structural formula of Amiton
General
Surname VG
other names
  • O , O- Diethyl- S - [2-diethylaminoethyl] thiophosphate
  • Amiton
  • Tetram
Molecular formula C 10 H 24 NO 3 PS
Brief description

colorless liquid

External identifiers / databases
CAS number 78-53-5
PubChem 6542
ChemSpider 6294
Wikidata Q419110
properties
Molar mass 269.34 g mol −1
Physical state

liquid

density

1.048 g cm −3

boiling point
  • 110 ° C (at 0.3 h Pa )
  • 315 ° C
solubility

soluble in water and organic solvents

Refractive index

1.4655 (27 ° C)

safety instructions
GHS hazard labeling
no classification available
Toxicological data

0.15 mg kg −1 ( LD 50 ,  rat ,  sc )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

VG is a chemical warfare agent from the chemical group of thiophosphoric acid esters . It is also known as Amiton or Tetram and is a predecessor of the nerve agent VX .

VG is a colorless liquid that has also been used as an insecticide and acaricide. It has been subject to the Chemical Weapons Convention since 1997 and is therefore no longer produced. Amiton and its oxalate were originally developed as a pesticide and were among the first phosphonothiolate esters synthesized by Ranajit Ghosh , a chemist with British Imperial Chemical Industries , in the 1950s. As a nerve agent, like most nerve agents, Amiton acts through the lungs and skin. As a warfare agent, VG was never manufactured and stored on an industrial scale, as there are considerable problems in production, storage and ammunition.

Analytics

The reliable determination of amitone and its degradation products or of impurities is possible after adequate sample preparation in a wide variety of materials by coupling gas chromatography with mass spectrometry .

See also

Individual evidence

  1. ^ A b c d e Stanley A. Greene: Sittig's Handbook of Pesticides and Agricultural Chemicals . William Andrew, 2013, ISBN 978-0-8155-1903-4 , pp. 1184 ( limited preview in Google Book search).
  2. ^ A b c Steven L. Hoenig: Compendium of Chemical Warfare Agents . Springer Science & Business Media, 2006, ISBN 978-0-387-69260-9 , pp. 88 ( limited preview in Google Book search).
  3. ↑ David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-24.
  4. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  5. ^ Entry on VG in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on July 31, 2018 or earlier.
  6. ↑ Eric Croddy, James J. Wirtz: Weapons of Mass Destruction An Encyclopedia of Worldwide Policy, Technology, and History . ABC-CLIO, 2005, ISBN 1-85109-490-3 , pp. 16 ( limited preview in Google Book search).
  7. ↑ VT Borrett, TH Gan, BR Lakeland, DR Leslie, RJ Mathews, ER Mattsson, S. Riddell, V. Tantaro: Gas chromatographic-mass spectrometric characterization of amiton and the recovery of amiton from concrete, paint, rubber and soil matrices. In: J Chromatogr A. 1003 (1-2), Jun 27, 2003, pp. 143-155. PMID 12899304

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