Vinblastine

Structural formula
General
Non-proprietary name	Vinblastine
other names	Vincaleukoblastin
Molecular formula	C 46 H 58 N 4 O 9
External identifiers / databases
EC number	212-734-0
ECHA InfoCard	100,011,577
PubChem	241903
ChemSpider	211446
DrugBank	DB00570
Wikidata	Q282629
Drug information
ATC code	L01 CA01
Drug class	Cytostatic indole alkaloid
properties
Molar mass	810.97 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 302-315-318-335
	P: 261-280-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Vinblastine ( trade name Velbe ^® ) is a chemotherapeutic agent that is used as a mitosis inhibitor in chemotherapy for cancer patients. Vinblastine binds to the protein tubulin and thus inhibits the formation of microtubules . During cell division , microtubules ensure that the respective chromosome pairs of the newly created cells are pulled apart. As a result, vinca alkaloids prevent cell division and thus particularly affect the rapidly dividing cells in tumors . They also block DNA and RNA synthesis . The group of vinca alkaloids also includes vincristine , vindesine and vinorelbine .

Occurrence

Pink Catharanthe

The natural substance vinblastine is one of the alkaloids and is found in the rose-colored Catharanthe ( Catharanthus roseus , formerly called Vinca rosea ). Vinblastine is the best-known representative of a whole group of alkaloids from this plant species, the so-called vinca alkaloids .

Analytics

For the qualitative and quantitative determination of vinblastatin, the coupling of HPLC with mass spectrometry can be used after appropriate sample preparation .

Individual evidence

↑ ^a ^b data sheet Vinblastine sulfate salt from Sigma-Aldrich , accessed on November 3, 2016 ( PDF ).
↑ Mutschler: drug effects . 8th edition p. 895.
↑ Kosjek T, Dolinšek T, Gramec D, Heath E, Strojan P, Serša G, Čemažar M: Determination of vinblastine in tumor tissue with liquid chromatography-high resolution mass spectrometry. , Talanta. 2013 Nov 15; 116: 887-93, PMID 24148490
↑ Gao S, Zhou J, Zhang F, Miao H, Yun Y, Feng J, Tao X, Chen W: Rapid and sensitive liquid chromatography coupled with electrospray ionization tandem mass spectrometry method for the analysis of paclitaxel, docetaxel, vinblastine, and vinorelbine in human plasma. , Ther Drug Monit. 2014 Jun; 36 (3): 394-400, PMID 24365981
↑ Choi YH, Yoo KP, Kim J: Supercritical fluid extraction and liquid chromatography-electrospray mass analysis of vinblastine from Catharanthus roseus. , Chem Pharm Bull (Tokyo). 2002 Sep; 50 (9): 1294-6, PMID 12237558

[sigma-1] ta sheet Vinblastine sulfate salt from Sigma-Aldrich , accessed on November 3, 2016 ( PDF ).

[Mutschler-2] Mutschler: drug effects . 8th edition p. 895.

[3] Kosjek T, Dolinšek T, Gramec D, Heath E, Strojan P, Serša G, Čemažar M: Determination of vinblastine in tumor tissue with liquid chromatography-high resolution mass spectrometry. , Talanta. 2013 Nov 15; 116: 887-93, PMID 24148490

[4] Gao S, Zhou J, Zhang F, Miao H, Yun Y, Feng J, Tao X, Chen W: Rapid and sensitive liquid chromatography coupled with electrospray ionization tandem mass spectrometry method for the analysis of paclitaxel, docetaxel, vinblastine, and vinorelbine in human plasma. , Ther Drug Monit. 2014 Jun; 36 (3): 394-400, PMID 24365981

[5] Choi YH, Yoo KP, Kim J: Supercritical fluid extraction and liquid chromatography-electrospray mass analysis of vinblastine from Catharanthus roseus. , Chem Pharm Bull (Tokyo). 2002 Sep; 50 (9): 1294-6, PMID 12237558