Xanthosine monophosphate
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Surname | Xanthosine monophosphate | |||||||||
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Molecular formula | C 10 H 13 N 4 O 9 P | |||||||||
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properties | ||||||||||
Molar mass | 364.21 g mol −1 | |||||||||
Physical state |
firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Xanthosine monophosphate ( XMP ) is a nucleotide and the phosphoric acid ester of the nucleoside xanthosine . It is a metabolic product that occurs in the two-step biosynthesis of guanosine monophosphate (GMP).
Xanthosine monophosphate is formed during the NAD + -dependent dehydrogenation of inosine monophosphate (IMP) by inosine monophosphate dehydrogenase (IMPDH). Through the transfer of a glutamine amide nitrogen, XMP is then converted to GMP by GMP synthase . This reaction is driven by the hydrolysis of adenosine triphosphate to adenosine monophosphate and pyrophosphate . Xanthosine monophosphate itself is not a component of ribonucleic acid despite its chemical association with ribonucleotides .
Like guanosine monophosphate, XMP acts as a flavor enhancer for the “salty” taste sensation .
Enzymes that involve XMP as a substrate or reaction product are u. a .:
- IMPDH, ( EC 1.1.1.205 )
- Xanthine Phosphoribosyltransferase, ( EC 2.4.2.22 )
- GMP synthase, ( EC 6.3.4.1 )
- GMP synthase (glutamine hydrolysing), ( EC 6.3.5.2 )
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ D. Voet, J. Voet, C. Pratt: Textbook of Biochemistry . 2nd Edition. Wiley-VCH, Weinheim 2010, ISBN 978-3-527-32667-9 , p. 890.
- ↑ a b entry on xanthosine. In: Römpp Online . Georg Thieme Verlag, accessed on December 29, 2014.