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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Solute carrier organic anion transporter family member 1B3''' (SLCO1B3) also known as '''organic anion-transporting polypeptide 1B3''' (OATP1B3) is a [[protein]] that in humans is encoded by the ''SLCO1B3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28234| accessdate = }}</ref>
'''Solute carrier organic anion transporter family member 1B3''' (SLCO1B3) also known as '''organic anion-transporting polypeptide 1B3''' (OATP1B3) is a [[protein]] that in humans is encoded by the ''SLCO1B3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28234}}</ref>


OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the [[portal vein]].
OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the [[portal vein]].


== Clinical significance ==
== Clinical significance ==
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.<ref name="pmid18519758">{{cite journal | vauthors = Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD | title = Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer | journal = Clin. Cancer Res. | volume = 14 | issue = 11 | pages = 3312–8 |date=June 2008 | pmid = 18519758 | pmc = 2701141 | doi = 10.1158/1078-0432.CCR-07-4118 | url = | issn = }}</ref> Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.<ref name="pmid21625523">{{cite journal | author = Heather Pressler | author2 = Tristan M. Sissung | author3 = David Venzon| author4 = Douglas K. Price | author5 = William D. Figg | title = Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression | journal = Clin. Cancer Res. | volume = 6 | issue = 5 | pages = e20372 |date=May 2011 | pmid = 21625523 | pmc = 3098289 | doi = 10.1371/journal.pone.0020372| issn = | bibcode = 2011PLoSO...620372P }}</ref>
OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.<ref name="pmid18519758">{{cite journal | vauthors = Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD | title = Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer | journal = Clin. Cancer Res. | volume = 14 | issue = 11 | pages = 3312–8 |date=June 2008 | pmid = 18519758 | pmc = 2701141 | doi = 10.1158/1078-0432.CCR-07-4118 }}</ref> Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.<ref name="pmid21625523">{{cite journal | author = Heather Pressler | author2 = Tristan M. Sissung | author3 = David Venzon| author4 = Douglas K. Price | author5 = William D. Figg | title = Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression| journal = PLOS ONE| volume = 6 | issue = 5 | pages = e20372 |date=May 2011 | pmid = 21625523 | pmc = 3098289 | doi = 10.1371/journal.pone.0020372| bibcode = 2011PLoSO...620372P | doi-access = free }}</ref>


In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.<ref name="pmid21625523" />
In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.<ref name="pmid21625523" />


==Substrates==
==Substrates==
Small molecules that are transported by SLCO1B3 include:<ref name="pmid18668430">{{cite journal | vauthors = Hagenbuch B, Gui C | title = Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family | journal = Xenobiotica | volume = 38 | issue = 7–8 | pages = 778–801 |date=July 2008 | pmid = 18668430 | doi = 10.1080/00498250801986951 | url = | issn = }}</ref>
Small molecules that are transported by SLCO1B3 include:<ref name="pmid18668430">{{cite journal | vauthors = Hagenbuch B, Gui C | title = Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family | journal = Xenobiotica | volume = 38 | issue = 7–8 | pages = 778–801 |date=July 2008 | pmid = 18668430 | doi = 10.1080/00498250801986951 | s2cid = 85868712 }}</ref>
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* [[Amanitin]]
* [[Amanitin]]
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161–8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 }}
*{{cite journal | vauthors=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161–8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 |doi-access= free }}
*{{cite journal |vauthors=Abe T, Unno M, Onogawa T, etal |title=LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers |journal=Gastroenterology |volume=120 |issue= 7 |pages= 1689–99 |year= 2001 |pmid= 11375950 |doi=10.1053/gast.2001.24804 }}
*{{cite journal |vauthors=Abe T, Unno M, Onogawa T, etal |title=LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers |journal=Gastroenterology |volume=120 |issue= 7 |pages= 1689–99 |year= 2001 |pmid= 11375950 |doi=10.1053/gast.2001.24804 |doi-access=free }}
*{{cite journal |vauthors=Ismair MG, Stieger B, Cattori V, etal |title=Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver |journal=Gastroenterology |volume=121 |issue= 5 |pages= 1185–90 |year= 2001 |pmid= 11677211 |doi=10.1053/gast.2001.28704 |url=http://www.zora.uzh.ch/id/eprint/3000/4/ZORA_3000.pdf }}
*{{cite journal |vauthors=Ismair MG, Stieger B, Cattori V, etal |title=Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver |journal=Gastroenterology |volume=121 |issue= 5 |pages= 1185–90 |year= 2001 |pmid= 11677211 |doi=10.1053/gast.2001.28704 |url=http://www.zora.uzh.ch/id/eprint/3000/4/ZORA_3000.pdf }}
*{{cite journal |vauthors=Jung D, Podvinec M, Meyer UA, etal |title=Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor |journal=Gastroenterology |volume=122 |issue= 7 |pages= 1954–66 |year= 2002 |pmid= 12055601 |doi=10.1053/gast.2002.33583 }}
*{{cite journal |vauthors=Jung D, Podvinec M, Meyer UA, etal |title=Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor |journal=Gastroenterology |volume=122 |issue= 7 |pages= 1954–66 |year= 2002 |pmid= 12055601 |doi=10.1053/gast.2002.33583 |doi-access=free }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal |vauthors=Cui Y, König J, Nies AT, etal |title=Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma |journal=Lab. Invest. |volume=83 |issue= 4 |pages= 527–38 |year= 2003 |pmid= 12695556 |doi= 10.1097/01.lab.0000065015.02412.48}}
*{{cite journal |vauthors=Cui Y, König J, Nies AT, etal |title=Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma |journal=Lab. Invest. |volume=83 |issue= 4 |pages= 527–38 |year= 2003 |pmid= 12695556 |doi= 10.1097/01.lab.0000065015.02412.48|doi-access=free }}
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal |vauthors=Vavricka SR, Jung D, Fried M, etal |title=The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma |journal=J. Hepatol. |volume=40 |issue= 2 |pages= 212–8 |year= 2004 |pmid= 14739090 |doi=10.1016/j.jhep.2003.10.008 }}
*{{cite journal |vauthors=Vavricka SR, Jung D, Fried M, etal |title=The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma |journal=J. Hepatol. |volume=40 |issue= 2 |pages= 212–8 |year= 2004 |pmid= 14739090 |doi=10.1016/j.jhep.2003.10.008 }}
*{{cite journal | vauthors=Hirano M, Maeda K, Shitara Y, Sugiyama Y |title=Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans |journal=J. Pharmacol. Exp. Ther. |volume=311 |issue= 1 |pages= 139–46 |year= 2004 |pmid= 15159445 |doi= 10.1124/jpet.104.068056 }}
*{{cite journal | vauthors=Hirano M, Maeda K, Shitara Y, Sugiyama Y |title=Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans |journal=J. Pharmacol. Exp. Ther. |volume=311 |issue= 1 |pages= 139–46 |year= 2004 |pmid= 15159445 |doi= 10.1124/jpet.104.068056 |s2cid=9691203 }}
*{{cite journal | vauthors=Letschert K, Keppler D, König J |title=Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8) |journal=Pharmacogenetics |volume=14 |issue= 7 |pages= 441–52 |year= 2005 |pmid= 15226676 |doi=10.1097/01.fpc.0000114744.08559.92 }}
*{{cite journal | vauthors=Letschert K, Keppler D, König J |title=Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8) |journal=Pharmacogenetics |volume=14 |issue= 7 |pages= 441–52 |year= 2005 |pmid= 15226676 |doi=10.1097/01.fpc.0000114744.08559.92 }}
*{{cite journal |vauthors=Yamaguchi H, Okada M, Akitaya S, etal |title=Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 |journal=J. Lipid Res. |volume=47 |issue= 6 |pages= 1196–202 |year= 2006 |pmid= 16534140 |doi= 10.1194/jlr.M500532-JLR200 }}
*{{cite journal |vauthors=Yamaguchi H, Okada M, Akitaya S, etal |title=Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 |journal=J. Lipid Res. |volume=47 |issue= 6 |pages= 1196–202 |year= 2006 |pmid= 16534140 |doi= 10.1194/jlr.M500532-JLR200 |s2cid=14682342 |url= http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/50391/3/06_20121105.pdf |doi-access= free }}
*{{cite journal |vauthors=Ohtsuka H, Abe T, Onogawa T, etal |title=Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene |journal=J. Gastroenterol. |volume=41 |issue= 4 |pages= 369–77 |year= 2006 |pmid= 16741617 |doi= 10.1007/s00535-006-1784-3 }}
*{{cite journal |vauthors=Ohtsuka H, Abe T, Onogawa T, etal |title=Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene |journal=J. Gastroenterol. |volume=41 |issue= 4 |pages= 369–77 |year= 2006 |pmid= 16741617 |doi= 10.1007/s00535-006-1784-3 |s2cid=7626543 }}
*{{cite journal |vauthors=Briz O, Romero MR, Martinez-Becerra P, etal |title=OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes? |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30326–35 |year= 2006 |pmid= 16877380 |doi= 10.1074/jbc.M602048200 }}
*{{cite journal |vauthors=Briz O, Romero MR, Martinez-Becerra P, etal |title=OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes? |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30326–35 |year= 2006 |pmid= 16877380 |doi= 10.1074/jbc.M602048200 |doi-access= free }}
*{{cite journal | vauthors=Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N |title=Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=293 |issue= 1 |pages= G271–8 |year= 2007 |pmid= 17412826 |doi= 10.1152/ajpgi.00075.2007 }}
*{{cite journal | vauthors=Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N |title=Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=293 |issue= 1 |pages= G271–8 |year= 2007 |pmid= 17412826 |doi= 10.1152/ajpgi.00075.2007 }}
*{{cite journal | vauthors=Treiber A, Schneiter R, Häusler S, Stieger B |title=Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil |journal=Drug Metab. Dispos. |volume=35 |issue= 8 |pages= 1400–7 |year= 2007 |pmid= 17496208 |doi= 10.1124/dmd.106.013615 }}
*{{cite journal | vauthors=Treiber A, Schneiter R, Häusler S, Stieger B |title=Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil |journal=Drug Metab. Dispos. |volume=35 |issue= 8 |pages= 1400–7 |year= 2007 |pmid= 17496208 |doi= 10.1124/dmd.106.013615 |s2cid=2625368 }}
*{{cite journal |vauthors=Muto M, Onogawa T, Suzuki T, etal |title=Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma |journal=Cancer Sci. |volume=98 |issue= 10 |pages= 1570–6 |year= 2007 |pmid= 17760952 |doi= 10.1111/j.1349-7006.2007.00570.x }}
*{{cite journal |vauthors=Muto M, Onogawa T, Suzuki T, etal |title=Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma |journal=Cancer Sci. |volume=98 |issue= 10 |pages= 1570–6 |year= 2007 |pmid= 17760952 |doi= 10.1111/j.1349-7006.2007.00570.x |s2cid=35010274 |doi-access=free }}
{{refend}}
{{refend}}


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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
[[Category: Thyroid hormone transporters]]




Latest revision as of 19:27, 31 December 2023

SLCO1B3
Identifiers
AliasesSLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3
External IDsOMIM: 605495; MGI: 1351899; HomoloGene: 75119; GeneCards: SLCO1B3; OMA:SLCO1B3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

28234

28253

Ensembl

ENSG00000111700

ENSMUSG00000030236

UniProt

Q9NPD5

Q9JJL3

RefSeq (mRNA)

NM_019844
NM_001349920

NM_020495
NM_178235

RefSeq (protein)

NP_062818
NP_001336849

NP_065241

Location (UCSC)Chr 12: 20.81 – 20.92 MbChr 6: 141.58 – 141.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.[5]

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance[edit]

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression.[6] Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.[7]

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.[7]

Substrates[edit]

Small molecules that are transported by SLCO1B3 include:[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111700 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030236 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SLCO1B3 solute carrier organic anion transporter family, member 1B3".
  6. ^ Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, Figg WD (June 2008). "Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer". Clin. Cancer Res. 14 (11): 3312–8. doi:10.1158/1078-0432.CCR-07-4118. PMC 2701141. PMID 18519758.
  7. ^ a b Heather Pressler; Tristan M. Sissung; David Venzon; Douglas K. Price; William D. Figg (May 2011). "Expression of OATP Family Members in Hormone-Related Cancers: Potential Markers of Progression". PLOS ONE. 6 (5): e20372. Bibcode:2011PLoSO...620372P. doi:10.1371/journal.pone.0020372. PMC 3098289. PMID 21625523.
  8. ^ Hagenbuch B, Gui C (July 2008). "Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family". Xenobiotica. 38 (7–8): 778–801. doi:10.1080/00498250801986951. PMID 18668430. S2CID 85868712.

Further reading[edit]


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