Alfred G. Redfield

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Alfred Guillou Redfield (born March 11, 1929 in Boston or Milton , Massachusetts , † July 24, 2019 ) was an American biophysicist and bioinformatician at Brandeis University . He was able to make significant contributions to nuclear magnetic resonance spectroscopy and is considered a pioneer in the application of this method to biomolecules . Redfield specializes in nuclear magnetic resonance and nuclear quadrupole resonance spectroscopy of proteins and nucleic acids . Areas of application were, for example, Ras-related proteins such as RAC or metalloenzymes using field cycling .

Life

Alfred Guillou Redfield is the third child of the oceanographer Alfred Clarence Redfield (1890-1983).

Alfred G. Redfield acquired in 1950 a Bachelor at the Harvard University and in 1952 a master and in 1953 a Ph.D. at the University of Illinois , the latter with a thesis on the Hall effect in diamonds and alkali metal - halogens . As a postdoctoral fellow , he worked at the later Nobel Laureate in Physics Nicolaas Bloembergen at Harvard University, where he is in the nuclear magnetic resonance (NMR) with the spin - Thermodynamics in the rotating frame of the disturbance of the theoretical aspects and relaxation dealt. In 1955 Redfield moved to the IBM Watson Laboratory at Columbia University (see Thomas J. Watson Research Center ). Here, in addition to the structure of type II fluoroxide lattices, he primarily examined normally conductive metals and superconductors using field cycling , extending the results of Hebel and Slichter under normal conditions to ultra-low temperature conditions (together with Arthur G. Anderson and Yoshika Masuda ).

From 1969 Redfield dealt with the NMR of biological materials. Together with Raj Gupta , he was able to demonstrate the transfer of electrons within the protein cytochrome c . After a two-year sabbatical with Daniel E. Koshland , Redfield moved to the Department of Physics and Biochemistry at Brandeis University in 1972 . Here he and his colleagues used pulsed Fourier transform NMR to investigate tRNA and G-protein Ras in particular , also using the nuclear Overhauser effect .

In 1999 Redfield retired , but remained scientifically active. He constructed a high-resolution field cycling NMR, with which he - together with Mary F. Roberts and based on the work of Seymour H. Koenig - examined various biomolecules.

The Redfield pulse sequence is named after Redfield .

Awards (selection)

Web links

Individual evidence

  1. ^ A b Peter J. le B. Williams: An Appreciation of Alfred C. Redfield and his Scientific Work. In: Limnology and Oceanography Bulletin. 15, 2006, p. 53, doi: 10.1002 / lob.200615453 .
  2. ^ A b John Andraos: Named Concepts in Chemistry (PDF, 407 kB) at York University (yorku.ca); accessed on April 15, 2018.
  3. ^ Lisa M. Lynch: Obituary for Alfred G. Redfield. In: Journal of Magnetic Resonance - News. Retrieved on August 2, 2019 .
  4. ^ A b Alfred G. Redfield. In: aps.org. Retrieved April 15, 2018 .
  5. ↑ Brandeis University - Department of Biochemistry  ( page no longer available , search in web archives ) (PDF, 410 kB, status 2009) in the Directory of Graduate Research of the American Chemical Society ; accessed on April 16, 2017.@1@ 2Template: Dead Link / dgr.rints.com
  6. ^ Alfred Redfield. In: nasonline.org. Retrieved April 15, 2018 .
  7. ↑ Book of Members 1780 – present, Chapter R. (PDF; 508 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved April 15, 2018 .
  8. ^ Remsen Award. In: maryland.sites.acs.org; accessed on April 15, 2018.
personal data
SURNAME Redfield, Alfred G.
ALTERNATIVE NAMES Redfield, Alfred Guillou
BRIEF DESCRIPTION American biophysicist
DATE OF BIRTH March 11, 1929
PLACE OF BIRTH Massachusetts
DATE OF DEATH July 24, 2019