Axel Fauser

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Axel Arthur Fauser (* 1948 ) is a German hematologist who, in collaboration with Hans Messner, has identified a common precursor cell for different blood cell lines in human blood .

Life

Axel Fauser studied medicine at the University of Freiburg im Breisgau and received his doctorate in 1975. After research work at the University of Toronto , he completed his habilitation in 1983 in the field of hematology in Freiburg. He then worked at the Royal Victoria Hospital of McGill University in Montreal and as a private lecturer in Freiburg. On the initiative of Stefan-Morsch Foundation he founded in 1994 one on stem cell specialized clinic at the hospital Idar-Oberstein the Saarland-Heilstätten and was its director until its closure in the year of 2010.

Based on the research results of Ernest McCulloch and James Till on mouse bone marrow cells , Fauser and Messner developed a functional assay that allows the process of multiplication and differentiation of human hematopoietic stem cells to be analyzed in vitro . In 1978 they were able to show for the first time that a pluripotent precursor cell exists that generates colonies of different blood cell lines. Precursor cells of these colonies are referred to as of the type CFU-GEMM (colony-forming for granulocytes , erythropoietic cells, megakaryopoietic cells and monocytes ). They lack the full ability of stem cells to self-renew because daughter colonies do not have the same composition. The assay was used to study the development of leukemia and to find factors that are effective in the early stages of a stem cell transplant.

Individual evidence

  1. ↑ Axel Fauser: Morphometry of the lungs in mitral stenosis . Diss., Freiburg (Breisgau) 1975. Catalog ub.uni-freiburg.de
  2. ↑ Axel A. Fauser: Detection and characterization of pluripotent myelolymphopoietic stem cells from human bone marrow . Habil., Freiburg (Breisgau) 1983. Catalog ub.uni-freiburg.de
  3. ↑ About us ( Memento from November 18, 2006 in the Internet Archive ) Clinic for Bone Marrow Transplantation and Hematology / Oncology GmbH, archived on November 18, 2006.
  4. ↑ Fauser defends himself: Practice not abandoned without warning . In: Rhein-Zeitung , accessed on September 14, 2011.
  5. ↑ AA Fauser, HA Messner: Granuloerythropoietic colonies in human bone marrow, peripheral blood, and cord blood . (PDF; 709 kB) In: Blood , 1978 Dec, 52 (6), pp. 1243-1248, PMID 719177 ; AA Fauser, HA Messner: Identification of megakaryocytes, macrophages, and eosinophils in colonies of human bone marrow containing neutrophilic granulocytes and erythroblasts . (PDF; 579 kB) In: Blood , 1979 May, 53 (5), pp. 1023-1027, accessed on May 13, 2009, PMID 435638 ; Carsten Griesel: Optimizing the cultivation of human ematopoietic stem and progenitor cells and their expansion in a miniaturized bioreactor system . (PDF; 2.5 MB) Dissertation Braunschweig, Technical University, Faculty of Life Sciences, 2008, p. 2, accessed on April 22, 2009.
  6. ^ Ernest A. McCulloch: Normal and Leukemic Hematopoietic Stem Cells and Lineages . In: Stewart Sell (ed.); Stem cells handbook . Humana Press, Totowa 2003, ISBN 1-58829-113-8 , p. 122, Google Book Search
personal data
SURNAME Fauser, Axel
ALTERNATIVE NAMES Fauser, Axel Arthur
BRIEF DESCRIPTION German hematologist
DATE OF BIRTH 1948