Benzethonium chloride

Structural formula
General
Surname	Benzethonium chloride
other names	Diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride; Benzethonii chloridum; Hyamine 1622; BENZETHONIUM CHLORIDE ( INCI ) ;
Molecular formula	C 27 H 42 ClNO 2
Brief description	white odorless hygroscopic solid
External identifiers / databases
EC number	204-479-9
ECHA InfoCard	100.004.073
PubChem	8478
ChemSpider	8165
Wikidata	Q425119
Drug information
ATC code	R02 AA09 , D08 AJ58
properties
Molar mass	448.09 g mol −1
Physical state	firmly
Melting point	160-166 ° C
solubility	soluble in water
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 301-314-410
	P: 273-280-301 + 330 + 331-305 + 351 + 338-308 + 310
Toxicological data	368 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Benzethonium chloride is a chemical compound from the group of quaternary ammonium salts , chlorides and phenol ether derivatives .

properties

Benzethonium chloride is a white, odorless, moisture-sensitive, hygroscopic, flammable solid with antimicrobial activity, which is easily soluble in water.

use

Benzethonium chloride is used as a preservative in the cosmetics industry and in pharmaceuticals . Benzethonium chloride is not approved for use in the food industry in Germany . In clinical diagnostics, it is used as a reagent for the determination of protein in urine and cerebrospinal fluid (CSF). As a cationic detergent, benzethonium chloride is also used in biochemistry as a protease inhibitor .

Web links

BfR: BgVV advises caution with products with grapefruit seed extracts due to contamination with benzethonium chloride , press release, July 21, 1998.
Entry on benzethonium chloride in the Pharmawiki

Individual evidence

↑ Entry on BENZETHONIUM CHLORIDE in the CosIng database of the EU Commission, accessed on July 11, 2020.
↑ ^a ^b ^c ^d ^e ^f ^g Entry on benzethonium chloride in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
↑ Applichem: benzethonium

[CosIng-1] Entry on BENZETHONIUM CHLORIDE in the CosIng database of the EU Commission, accessed on July 11, 2020.

[GESTIS-2] ↑ ^a ^b ^c ^d ^e ^f ^g Entry on benzethonium chloride in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .

[3] Applichem: benzethonium