Boris Zemelman

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Boris Valery Zemelman (born September 10, 1967 ) is an American neuroscientist of Russian origin. He is considered to be one of the pioneers of the new science of optogenetics .

Career

Boris Zemelman came to the United States in Wilton, Connecticut, in 1978 at the age of ten as the son of Russian immigrants Valery and Evelina Zemelman . There he attended Wilton High School, from which he graduated in 1985 and was awarded the Charles G. Mortimer Scholarship for his excellent academic performance .

Zemelman studied biochemistry at Stanford University , where he in 1997 with a dissertation on Purification and characterization of a novel mammalian recombinase at I. Robert Lehman doctorate was.

Zemelman is an Assistant Professor of Neuroscience at the Center for Learning and Memory at the University of Texas at Austin . He is also doing research as a visiting scientist at the Dudman Lab on the Janelia Farm Research Campus .

Research activity

After completing his dissertation , Zemelman initially devoted himself to research on SNARE proteins such as synaptobrevin and their influence on intracellular membrane fusion .

Zemelman gained notoriety through his joint research work with Gero Miesenböck in 2002 and 2003 on the selective light stimulation of neurons , which are considered to be the basis of the new research branch of optogenetics, which was further developed by Karl Deisseroth in 2005. In specialist circles, these three scientists were jointly traded as an insider tip for the 2013 Nobel Prize . Zemelman and Miesenböck first used rhodopsin and arrestin of Drosophila as photoreceptors in cultivated mammalian neurons to control neuron activity. Then they developed ion channels as switches for controlling optical and pharmacological stimuli .

Zemelman is currently researching the role of the hippocampus in the development of consciousness .

honors and awards

  • 1985: Charles G. Mortimer Scholarship

Fonts (selection)

  • Purification and characterization of a novel mammalian recombinase , Stanford University dissertation 1997.

Web links

Individual evidence

  1. ↑ Persons born on September 10, 1967 on the SortedByBirthDate.com website
  2. ↑ a b Martha Slater: Russian Immigrant, 90, hopes to be Citizen , in: Randolph Herald of October 16, 2003
  3. ↑ a b Boris Zemelman as a prediction for the Nobel Prize 2013 ( Memento from November 12, 2014 in the Internet Archive ) on the Understanding Animal Research website
  4. ^ A b Edward S. Boyden : The Birth of Optogenetics. An account of the path to realizing tools for controlling brain circuits with light , in: The Scientist Magazine of July 1, 2011
  5. ^ A b Lief Fenno, Ofer Yizhar and Karl Deisseroth: The Development and Application of Optogenetics , in: Annual Review of Neuroscience , Volume 34 (2011), pp. 389-412, here pp. 390f.
  6. ^ A b Gordon E. Fairclough: Wilton students reap awards for excellence , in: The Hour of June 11, 1985, pp. 9f. on Google News archive search
  7. ↑ Listing of the dissertation on the Worldcat.org website
  8. ↑ Boris V. Zemelman on the website neurotree.org
  9. ↑ a b Boris Zemelman's faculty page on the website of the Center for Learning and Memory at the University of Texas , Austin
  10. ↑ Boris Zemelman's Visiting Scientist page ( memento from January 10, 2014 in the Internet Archive ) on the Janelia Farm Research Campus website
  11. ↑ Thomas Weber, Boris V. Zemelman, James A McNew, Benedikt Westermann, Michael Gmachel, Francesco Parlati, Thomas H. Söllner and James E. Rothman : SNAREpins: Minimal Machinery for Membrane Fusion , in: Cell , Vol. 92,6, 20 March 1998, pp. 759-772
  12. ↑ joint patents of Boris V. Zemelman and Gero Miesenböck on the website Justia Patents
  13. ↑ a b Boris V. Zemelman, Georgia A. Lee, Minna Ng and Gero Mieseböck: Selective Photostimulation of Genetically ChARGed Neurons , in: Neuron , Volume 33, No. 1, January 3, 2002, pp. 15-22
  14. ↑ a b Boris V. Zemelman, Nasri Nesnan, Georgia A. Lee and Gero Miesenböck: Photochemical gating of heterologous ion channels: Remote control over genetically designated populations of neurons , in: PNAS , Volume 100, No. 3 (2003), p 1352-1357
  15. ↑ Attila Losonczy, Boris V. Zemelman, Alipasha Vaziri and Jeffrey C Magee: Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons , in: Nature Neuroscience , Volume 13, No. 8 (2010), pp. 967-972.
  16. ↑ Sébastien Royer, Boris V. Zemelman, Attila Losonczy, Jinhyun Kim, Frances Chance, Jeffrey C. Magee and György Buzsáki: Control of timing, rate and bursts of hippocampal place cells by dendtitic and somatic inhibition , in: Nature Neuroscience, Volume 15 , No. 5 (2012), pp. 769-775.
personal data
SURNAME Zemelman, Boris
ALTERNATIVE NAMES Zemelman, Boris V .; Zemelman, Boris Valery (full name)
BRIEF DESCRIPTION American neuroscientist of Russian descent
DATE OF BIRTH September 10, 1967