Butetamate

from Wikipedia, the free encyclopedia
Structural formula
Butetamate.svg
Structural formula without stereochemistry
General
Non-proprietary name Butetamate
other names
  • ( RS ) -2- (Diethylamino) ethyl-2-phenylbutanoate ( IUPAC )
Molecular formula
  • C 16 H 25 NO 2 (butetamate)
  • C 16 H 25 NO 2 C 6 H 8 O 7 (butetamate citrate )
External identifiers / databases
CAS number
  • 14007-64-8 (butetamate)
  • 3639-12-1 (butetamate citrate)
  • 13900-12-4 (butetamate dihydrogen citrate)
EC number 237-817-9
ECHA InfoCard 100.034.366
PubChem 27368
ChemSpider 25466
Wikidata Q1017896
Drug information
ATC code

R05 DB30

Drug class

Antitussives

properties
Molar mass
  • 263.38 g · mol -1 (Butetamat)
  • 455,50 g · mol -1 (Butetamat · citrate)
Physical state

firmly

Melting point

109–110 ° C (butetamate citrate)

solubility

Easily soluble in water and ethanol (butetamate citrate)

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances

Citrate

no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Butetamate is a drug that was used as an antitussive ("cough blocker").

Its cough suppressant effect corresponds roughly to that of codeine , but in contrast to this it has only a very weak analgesic effect , has a bronchodilator effect , has no potential for dependence , does not affect the ability to react and does not lead to respiratory depression .

Chemistry and isomerism

The drug is structurally related to methadone . Butetamate is chiral and was used as a 1: 1 mixture ( racemate ) of ( R ) and ( S ) enantiomers .

Chemically related active ingredients ( analogues ) are butamirate , oxeladine and pentoxyverine .

Trade names

Pertix-Hommel (D, except trade)

Individual evidence

  1. ^ A b The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 250, ISBN 978-0-911910-00-1 .
  2. ↑ a b data sheet Butethamate citrate salt from Sigma-Aldrich , accessed on May 22, 2017 ( PDF ).
  3. ↑ CJ Estler (Ed.): Pharmacology and Toxicology. 4th edition. Schattauer, Stuttgart and New York 1995, pp. 273-276.
  4. ^ HJ Roth and H. Fenner: Medicines. Thieme, Stuttgart and New York 1988, pp. 542-545.