Butorphanol

Structural formula
General
Non-proprietary name	Butorphanol
other names	(+) - 17- (cyclobutylmethyl) morphinan-3,14-diol Stadol
Molecular formula	C 21 H 29 NO 2
Brief description	white solid
External identifiers / databases
CAS number 42408-82-2 58786-99-5 ( tartrate ) EC number 255-808-8 ECHA InfoCard 100.050.717 PubChem 5361092 ChemSpider 16735714 DrugBank DB00611 Wikidata Q1185089
Drug information
ATC code	N02 AF
Drug class	Opioid - analgesic
properties
Molar mass	327.46 g · mol -1 (base) 477.55 (tartrate)
Physical state	firmly
Melting point	216 ° C (base)
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances Tartrate Caution H and P phrases H: 302-361 P: 201-301 + 312 + 330-308 + 313
Toxicological data	35 μg kg −1 ( TD Lo , human (woman) , intraspinal , base)
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Butorphanol is a strong pain reliever ( analgesic ) from the group of opioids . It acts as an agonist on the κ and δ opioid receptors and an antagonist on the μ − opioid receptor . Butorphanol is used as a veterinary medicinal product.

Finished medicinal products

Dolorex ad us.vet. ( D ), Torbugesic ad us.vet. (D)

literature

• Anne Rollmann: Examination of the analgesic potency of different dosages of butorphanol and buprenorphine after intravenous administration in dogs using a thermal and mechanical pain test (PDF; 893 kB) Dissertation, University of Veterinary Medicine Hannover, 2011.

Individual evidence

1. ^ Martindale: The Complete Drug Reference . 36th edition. Pp. 1-32.
2. ↑ ^{a b} Entry on butorphanol in the ChemIDplus database of the United States National Library of Medicine (NLM) .
3. ↑ ^{a b} data sheet butorphanol (+) - tartrate salt, ≥99% from Sigma-Aldrich , accessed on June 10, 2020 ( PDF ).
4. ↑ Entry on Butorphanol in Pharmawiki , accessed on January 28, 2017.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !