Cefaloglycine
Structural formula | ||||||||||||||||||||||
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General | ||||||||||||||||||||||
Non-proprietary name | Cefaloglycine | |||||||||||||||||||||
other names | ||||||||||||||||||||||
Molecular formula | C 18 H 19 N 3 O 6 S | |||||||||||||||||||||
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Drug information | ||||||||||||||||||||||
Drug class | ||||||||||||||||||||||
Mechanism of action |
Disturbance of cell wall synthesis |
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properties | ||||||||||||||||||||||
Molar mass | 405.43 g · mol -1 | |||||||||||||||||||||
Physical state |
firmly |
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Melting point |
237 ° C |
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solubility |
154 mg l −1 |
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safety instructions | ||||||||||||||||||||||
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Toxicological data | ||||||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Cefaloglycine is an antibiotic that was used to treat severe infections caused by susceptible bacteria. It is produced semisynthetically and belongs to the class of cephalosporins of the 1st generation.
Cefaloglycine is no longer commonly used.
indication
Cefalogylcine is effective against gram-positive cocci with the exception of enterococci . Apart from Pseudomonas aeruginosa , Klebsiella and indole-positive Proteus species , it is also effective against gram-negative bacteria.
Working principle
The cefaloglycine molecules bind - like all cephalosporins - to specific penicillin-binding proteins , which are required for the reconstruction of the bacterial cell wall. This prevents further synthesis of the bacterial cell wall.
Application
Cefaloglycine is given orally and is rapidly absorbed into the bloodstream .
Side effects
After an overdose, side effects such as nausea, vomiting, stomach upset, diarrhea and cramps may occur after oral ingestion of cefaloglycine.
Individual evidence
- ↑ a b c d e Entry on cephaloglycine in the DrugBank of the University of Alberta , accessed on May 22, 2019.
- ↑ a b XiXisys: Cefaloglycine , accessed on May 26, 2019.
- ↑ Entry on cephaloglycine in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on December 26, 2019.
- ^ A b Gunter Schmidt: Cephalosporins . In: Chemistry in Our Time . tape 10 , no. 6 , 1976, p. 189-195 , doi : 10.1002 / ciuz.19760100605 .