Clofibric acid

Structural formula
General
Surname	Clofibric acid
other names	2- (4-chlorophenoxy) isobutylic acid; 2- ( p -chlorophenoxy) -2-methylpropionic acid;
Molecular formula	C 10 H 11 ClO 3
Brief description	white solid
External identifiers / databases
EC number	212-925-9
ECHA InfoCard	100,011,751
PubChem	2797
ChemSpider	2695
Wikidata	Q3080279
properties
Molar mass	214.65 g mol −1
Physical state	firmly
density	1.23 g cm −3
Melting point	119-120 ° C
solubility	sparingly soluble in water (0.58 g l −1 at 20 ° C); soluble in methanol , ethanol and chloroform ;
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 302
	P: 264-270-301 + 312-330-501
Toxicological data	897 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Clofibric acid is a chemical compound from the group of aryloxyalkanecarboxylic acids .

Extraction and presentation

Clofibric acid can be obtained by reacting p-chlorophenol with acetone and chloroform in the presence of sodium hydroxide .

properties

Clofibric acid is a white solid that is sparingly soluble in water.

use

Clofibric acid and its derivatives are used as a drug to lower blood cholesterol . The related compound mecoprop is used as a plant growth regulator.

safety instructions

Some derivatives of clofibric acid known as fibrates (for example clofibrate or bezafibrate ) are metabolized to form this in the body. This accumulates in the groundwater due to its high microbial persistence and low sorption capacity .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Data sheet 2- (4-Chlorophenoxy) isobutyric acid, 98% from AlfaAesar, accessed on March 4, 2018 ( PDF )(JavaScript required) .
^ Carl L. Yaws: Thermophysical Properties of Chemicals and Hydrocarbons . William Andrew, 2014, ISBN 978-0-323-29060-9 , pp. 308 ( limited preview in Google Book search).
^ ^A ^b Olivier Thomas, Christopher Burgess: UV-Visible Spectrophotometry of Water and Wastewater . Elsevier, 2017, ISBN 978-0-444-63900-4 , pp. 447 ( limited preview in Google Book search).
↑ PPDB: clofibric acid , accessed March 4, 2018
↑ Data sheet 2- (p-Chlorophenoxy) -2-methylpropionic acid, 97% from Sigma-Aldrich , accessed on March 4, 2018 ( PDF ).
^ Clemens Lamberth, Jürgen Dinges: Bioactive Carboxylic Compound Classes Pharmaceuticals and Agrochemicals . John Wiley & Sons, 2016, ISBN 978-3-527-69396-2 , pp. 47 ( limited preview in Google Book search).
↑ E. Oberdisse, E. Hackenthal: Pharmacology and Toxicology . Springer-Verlag, 2013, ISBN 978-3-642-56314-0 , pp. 555 ( limited preview in Google Book search).
↑ clofibric acid data sheet , accessed March 4, 2018.
↑ Traugott Scheytt, Susanne Grams, Holger Fell: Occurrence and behavior of a drug (clofibric acid) in groundwater . In: groundwater . tape 3 , no. 2 , June 1, 1998, pp. 67-77 , doi : 10.1007 / s767-1998-8568-1 ( PDF ).
↑ Traugott Scheytt, Susanne Grams, Holger Fell: Occurrence and behavior of a drug (clofibric acid) in groundwater. In: groundwater. 3, 1998, p. 67, doi : 10.1007 / s767-1998-8568-1 .

[Alfa-1] ↑ ^a ^b ^c ^d ^e ^f ^g Data sheet 2- (4-Chlorophenoxy) isobutyric acid, 98% from AlfaAesar, accessed on March 4, 2018 ( PDF )(JavaScript required) .

[Carl_L._Yaws-2] Carl L. Yaws: Thermophysical Properties of Chemicals and Hydrocarbons . William Andrew, 2014, ISBN 978-0-323-29060-9 , pp. 308 ( limited preview in Google Book search).

[Olivier_Thomas,_Christopher_Burgess-3] A ^b Olivier Thomas, Christopher Burgess: UV-Visible Spectrophotometry of Water and Wastewater . Elsevier, 2017, ISBN 978-0-444-63900-4 , pp. 447 ( limited preview in Google Book search).

[herts.ac.uk-4] PPDB: clofibric acid , accessed March 4, 2018

[Sigma-5] Data sheet 2- (p-Chlorophenoxy) -2-methylpropionic acid, 97% from Sigma-Aldrich , accessed on March 4, 2018 ( PDF ).

[Clemens_Lamberth,_Jürgen_Dinges-6] Clemens Lamberth, Jürgen Dinges: Bioactive Carboxylic Compound Classes Pharmaceuticals and Agrochemicals . John Wiley & Sons, 2016, ISBN 978-3-527-69396-2 , pp. 47 ( limited preview in Google Book search).

[E._Oberdisse,_E._Hackenthal-7] E. Oberdisse, E. Hackenthal: Pharmacology and Toxicology . Springer-Verlag, 2013, ISBN 978-3-642-56314-0 , pp. 555 ( limited preview in Google Book search).

[alanwood.net-8] ric acid data sheet , accessed March 4, 2018.

[scheytt-9] Traugott Scheytt, Susanne Grams, Holger Fell: Occurrence and behavior of a drug (clofibric acid) in groundwater . In: groundwater . tape 3 , no. 2 , June 1, 1998, pp. 67-77 , doi : 10.1007 / s767-1998-8568-1 ( PDF ).

[DOI10.1007/s767-1998-8568-1-10] Traugott Scheytt, Susanne Grams, Holger Fell: Occurrence and behavior of a drug (clofibric acid) in groundwater. In: groundwater. 3, 1998, p. 67, doi : 10.1007 / s767-1998-8568-1 .