Eckhard Thiel

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Eckhard Thiel 2011

Eckhard Thiel (born April 30, 1944 in Tübingen ) is a German hematologist and oncologist . Until his retirement in 2011, he was Professor of Internal Medicine at the Charité in Berlin. The focus of his medical and scientific work was on cancers of the blood and immune system, leukemia and lymphoma .

life and work

Eckhard Thiel is the son of the neurologist Otto Thiel and his wife Ruth, b. Singer. In his hometown of Tübingen he first attended the Silcher elementary school from 1950 to 1953 and then the humanistic Uhland high school up to the Abitur in 1963. From 1963 he studied medicine at the Eberhard Karls University of Tübingen and in Vienna, which he studied in Tübingen in August 1969 with the Finished medical state examination . He received his doctorate in Tübingen in August 1969 on “Pathological spontaneous activity in waking and sleeping. Continuous electromyographic and electroencephalographic registration ”.

During his time as a medical assistant, he worked at the University of Tübingen's Surgical Clinic in 1969 and 1970, as well as at the University Medical Center and the Institute of Hygiene at the University of Tübingen. The license to practice medicine took place on October 31, 1970. From 1971 Thiel worked as a scientific assistant at the Institute for Hematology and Immunology of the Society for Radiation Research and Environmental Protection (GSF) in Munich under Stefan Thierfelder and also as an assistant doctor at the I. Medical Clinic of the University of Munich under Herbert Schwiegk.

At the GSF institute he developed a research focus on immunocytological and molecular genetic methods for diagnosing haemato-oncological diseases, especially leukemia . His laboratory area has become the central reference laboratory for pediatric and adult therapy studies, e.g. B. the nationwide clinical ALL therapy study (head: Dieter Hoelzer ), to which 120 clinics in the Federal Republic of Germany were connected.

In November 1977 he received medical certification as an internist . This was followed by further training in hematology and oncology as a ward doctor at the Medical Clinic III of the Großhadern Clinic under Wolfgang Wilmanns . In January 1979 he completed his habilitation in the field of internal medicine . In July 1981 he acquired the sub-areas of hematology and clinical transfusion medicine.

From 1981 to 1988 Thiel was senior physician and head of the hematology / oncology section of the Inner City Medical Clinic of the University of Munich under Ernst Buchborn. There he was appointed adjunct professor in February 1985.

From March 1988 he held a C4 chair for internal medicine with a focus on hematology and oncology in Berlin and was director of the Medical Clinic III for hematology, oncology and transfusion medicine at the Steglitz University Hospital , then at the Benjamin Franklin University Hospital and from 1998 at the Charité University Medicine up to his retirement in October 2011.

The director Mira Thiel is his daughter, from his marriage to the Bulgarian doctor Antonia Thiel.

Scientific activity

In addition to the immunodiagnostics and molecular genetic analysis of leukemia and lymphoma with a nationwide reference laboratory and cell bank, Thiel's clinical-scientific focus included the establishment of a unit for bone marrow stem cell transplantation at his clinic for the advanced therapy of leukemia, malignant lymphoma, plasmacytomas and other tumor diseases. In addition to antibody therapies and tumor vaccinations - the latter in collaboration with the Osaka University Medical Center - the therapy of malignant lymphomas was advanced through a nationwide study in CNS lymphomas , which Thiel led with Michael Weller. In the 1990s he established psycho-oncology and sports medicine for cancer patients in his clinic. In infectious diseases , progress has been made in particular with organ mycoses in immunosuppressed patients, as has HIV.

An HIV patient with leukemia was cured for the first time by transplanting genetically HIV-resistant stem cells. The story of this patient, Timothy Ray Brown , was filmed for Arte in 2012 as “Der Berliner Patient / Guérir du VIH - Un nouvel espoir” by his daughter Mira Thiel and Benjamin Cantu .

Awards

  • 1979: Vincenz-Czerny Prize of the German Society for Hematology and Oncology
  • 1981: Albert Knoll Prize of the Saarland-Palatinate Internist Society
  • 1989: Winner of the German Cancer Prize , clinical part, together with Dieter Hoelzer
  • 1994: Cavalier Cross of the Order of Merit of the Republic of Poland by President Lech Walesa
  • 2005: Honorary Doctorate and Honorary Professor from the National University of Almaty , Kazakhstan
  • 2011: Ernst von Leyden Medal of the Society for Internal Medicine, Berlin
  • 2012: Appointment as Clinical Development Advisor of the California Institute For Regenerative Medicine (CIRM)
  • 2014: Visiting professor at the Graduate School of Medicine, Osaka University

Fonts

  • Pathological spontaneous activity in waking and sleeping. Dissertation, University of Tübingen, 1969
  • Immunautoradiography for the diagnosis of leukemia. Habilitation thesis, University of Munich, 1979
  • With Stefan Thierfelder, Hans Rodt: Immunological Diagnosis of Leukemias and Lymphomas, Springer-Verlag, Berlin, Heidelberg, New York, Haematology and Blood Transfusion Vol. 20, 1977
  • With Stefan Thierfelder: Leukemia, Recent Developments in Diagnosis and Therapy, Springer Verlag, Berlin, Heidelberg, New York, Tokyo, Recent Results in Cancer Research Vol. 93, 1984
  • With Wolf-Dieter Ludwig: Recent Advances in Cell Biology of Acute Leukemia. Springer-Verlag, Berlin, Heidelberg, New York, London, Paris, Tokyo, Barcelona, ​​Budapest, Recent Results in Cancer Research Vol. 131, 1993
  • Personalized treatment of cancer: utopia or chance? German Medical Weekly, 135, 1851, 2010

Web links

Individual evidence

  1. ↑ Birth certificate no. 736/1944, Tübingen registry office.
  2. ↑ GSF
  3. ↑ Heinz Götze: The Springer publishing house, stations of its history . Ed .: Springer-Verlag. Part II: 1945-1929. Springer-Verlag, Berlin / Heidelberg / New York / London / Paris / Tokyo / Hong Kong / Barcelona / Budapest 1994, ISBN 3-540-56691-0 .
  4. ^ German Multicenter Study Group on Adult Acute Lymphoblastic Leukemia (GMALL). Retrieved June 22, 2020 .
  5. ^ Vita Mira Thiel. Retrieved June 22, 2020 .
  6. ↑ Stefan Thief Elder, Hans Rodt, Eckhard Thiel: Immunological Diagnosis of Leukemias and Lymphomas . In: Springer-Verlag (Ed.): International Symposium of the Institute for Hematology . tape 20 . Springer-Verlag, ISBN 3-540-08216-6 , pp. 387 .
  7. ↑ W.-D. Ludwig and E. Thiel: Recent Advances in Cell Biology of Acute Leukemia . In: Springer-Verlag (Ed.): Recent Results in Caner Research . tape 131 . Springer-Verlag, Berlin / Heidelberg / New York / London / Paris / Tokyo / Hong Kong / Barcelona 1993, ISBN 3-540-56417-9 , pp. 407 .
  8. ^ E. Thiel and S. Thierfelder: Leukemia . In: Springer-Verlag (Ed.): Recent Results in Cancer Research . tape 93 . Springer-Verlag, Berlin / Heidelberg / New York / Tokyo 1984, ISBN 3-540-13289-9 , pp. 304 .
  9. ↑ Carmen Scheibenbogen, Anne Letsch, Eckhard Thiel, Alexander Schmittel, Volker Mailaender, Steffi Baerwolf, Dirk Nargorsen, Ulrich Keilholz: CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia . Ed .: Blood. tape 100 . Blood, September 15, 2002, p. 2132-2137 .
  10. ↑ Dirk Nagorsen, Carmen Scheibenbogen, Eckhard Thiel, Ulrich Keilholz: Immunological Monitoring of Cancer Vaccine Therapy . Ed .: Expert Opinion Biology Therapies. tape 4 , no. 10 . Expert Opinion Biology Therapies, October 2004, p. 1677-1687 .
  11. ↑ Eckhard Thiel, Agnieszka Korfel, Peter Martus, Lothar Kanz, Frank Griesinger, Michael Rauch, Alexander Röth, Bernd Hertenstein, Theda von Toll, Thomas Hundsberger, Hans-Günther Mergenthaler, Malte Leithäuser, Tobias Birnbaum, Lars Fischer, Kristoph Jahnke, Ulrich Herrlinger, Ludwig Plasswilm, Thomas Nägele, Torsten Pietsch, Michael Bamberg, Michael Weller: High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomized, non-inferiority trial . Ed .: The Lancet. Oncology. tape 11 , November 2010, p. 1036-1047 .
  12. ↑ Lauren E Abrey 1, Tracy T Batchelor, Andrés JM Ferreri, Mary Gospodarowicz, Elisa J Pulczynski, Emanuele Zucca, Justine R Smith, Agnieszka Korfel, Carole Soussain, Lisa M DeAngelis, Edward A Neuwelt, Brian Patrick O'Neill, Eckhard Thiel , Tamara Shenkier, Fransesc Graus, Martin van den Bent, John F Seymour, Philip Poortmans, James O Armitage, Franco Cavalli, International Primary CNS Lymphoma Collaborative Group: Report of an International Workshop to Standardize Baseline Evaluation and Response Criteria for Primary CNS Lymphoma . Ed .: Journal of Clinical Oncology. 11th edition. No. 11 . Journal of Clinical Oncology, August 1, 2005, pp. 5034-5043 .
  13. ↑ Fernando Dimeo, Eckhard Thiel: Does Psychotherapy Affect the Survival of Cancer Patients? More Questions Than Answers . Ed .: Journal of Clinical Oncology. tape 25 , no. 35 . Journal of Clinical Oncology, December 10, 2007, pp. 5664-5 .
  14. ↑ Fernando Dimeo, Alexander Schmittel, Thomas Fietz, Stefan Schwartz, Peter Köhler, Dieter Böning, Eckhard Thiel: Physical Performance, Depression, Immune Status and Fatigue in Patients With Hematological Malignancies After Treatment . Ed .: Annals of Oncology. tape 15 , no. 8 . Annals of Oncology, August 2004, pp. 1237-42 .
  15. ↑ Fernando Dimeo, Stefan Schwartz, Norbert Wesel, Anton Voigt, Eckhard Thiel: Effects of an Endurance and Resistance Exercise Program on Persistent Cancer-Related Fatigue After Treatment . Ed .: Annals of Oncology. tape 19 , no. 8 . Annals of Oncology, August 2008, pp. 1495-9 .
  16. Jump up ↑ Raoul Herbrecht 1, David W Denning, Thomas F Patterson, John E Bennett, Reginald E Greene, Jörg-W Oestmann, Winfried V Kern, Kieren A Marr, Patricia Ribaud, Olivier Lortholary, Richard Sylvester, Robert H Rubin, John R Wingard , Paul Stark, Christine Durand, Denis Caillot, Eckhard Thiel, Pranatharthi H Chandrasekar, Michael R Hodges, Haran T Schlamm, Peter F Troke, Ben de Pauw, Invasive Fungal Infections Group of the European Organization for Research and Treatment of Cancer and the Global Aspergillus Study Group: Voriconazole Versus Amphotericin B for Primary Therapy of Invasive Aspergillosis . Ed .: The New England Journal of Medicine. tape 347 , no. 6 . The New England Journal of Medicine, Aug. 8, 2002, pp. 408-15 .
  17. ↑ Stefan Schwartz, Markus Ruhnke, Patricia Ribaud, Lawrence Corey, Timothy Driscoll, Oliver A Cornely, Ulrich Schuler, Irja Lutsar, Peter Troke, Eckhard Thiel: Improved Outcome in Central Nervous System Aspergillosis, Using Voriconazole Treatment . Ed .: Blood. tape 106 , no. 8 . Blood, October 15, 2005, p. 2641-5 .
  18. ↑ Udo Badelt: A diamond that shines in secret. Tagesspiegel, February 7, 2010, accessed on March 13, 2020 .
  19. ^ Donald G. McNeil Jr .: Rare Treatment Is Reported to Cure AIDS Patient. In: New York Times. New York Times, November 13, 2008, accessed March 13, 2020 .
  20. ↑ Gero Hütter, Daniel Nowak, Maximilian Mossner, Susanne Ganepola, Arne Müßig, Kristina Allers, Thomas Schneider, Jörg Hofmann, Claudia Kücherer, Olga Blau, Igor W. Blau, Wolf K. Hofmann, Eckhard Thiel: Long-Term Control of HIV by CCR5 Delta32 / Delta32 Stem-Cell Transplantation . New England Journal of Medicine 2009, Volume 360, Issue 7, Feb. 12, 2009, pages 692-698, doi: 10.1056 / NEJMoa0802905
  21. ↑ Kristina Allers, Gero Hütter, Jörg Hofmann, Christoph Loddenkemper, Kathrin Rieger, Eckhard Thiel, Thomas Schneider: Evidence for the Cure of HIV Infection by CCR5 Δ32 / Δ32 Stem Cell Transplantation . Ed .: Blood. tape 117 , no. 10 . Blood, March 10, 2011, p. 2791-9 .
  22. ↑ THE BERLIN PATIENT. Retrieved June 22, 2020 (English).
personal data
SURNAME Thiel, Eckhard
BRIEF DESCRIPTION German hematologist and oncologist
DATE OF BIRTH April 30, 1944
PLACE OF BIRTH Tübingen