Ethirimol

Structural formula
General
Surname	Ethirimol
other names	5-butyl-2- (ethylamino) -6-methylpyrimidin-4-ol; Milgo; Milstem;
Molecular formula	C 11 H 19 N 3 O
Brief description	colorless crystals
External identifiers / databases
EC number	245-949-3
ECHA InfoCard	100,041,758
PubChem	32152
Wikidata	Q3059320
properties
Molar mass	209.29 g mol −1
Physical state	firmly
density	1.21 g cm −3
Melting point	159–160 ° C ( phase change at approx. 140 ° C)
boiling point	decomposes
solubility	very heavy in water (0.253 g l −1 at 20 ° C and pH 5.5)
safety instructions
GHS hazard labeling from Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary Caution
H and P phrases	H: 312
	P: 280
Toxicological data	6340 mg kg −1 ( LD 50 , rat , oral ) ; 4000 mg kg −1 ( LD 50 , rat , oral ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Ethirimol is a chemical compound from the group of hydroxy- (2-amino) -pyrimidines, which ICI (now Syngenta ) introduced in 1968 as a fungicide . There it is one of the 2-aminopyrimidine fungicides .

Extraction and presentation

Ethirimol can be obtained by reacting 2-butyl-ethylacetoacetate with ethylguanidine .

use

Ethirimol is used as a protective and curative, systemic fungicide against powdery mildew . The effect is based on inhibition of adenosine deaminase (ADAase). It is also the main metabolite of bupirimate .

Admission

Ethirimol was approved in the FRG from 1971 to 1991. No plant protection products containing this active ingredient are permitted in the EU or Switzerland .

Individual evidence

↑ ^a ^b ^c ^d ^e Entry on Ethirimol. In: Römpp Online . Georg Thieme Verlag, accessed on May 24, 2014.
↑ ^a ^b ^c ^d ^e ^f Entry on ethirimol in the GESTIS substance database of the IFA , accessed on February 9, 2017(JavaScript required) .
↑ Entry on Ethirimol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 549 ( limited preview in Google Book search).
↑ Directorate-General for Health and Food Safety of the European Commission: Entry on Ethirimol in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.

[roempp-1] Entry on Ethirimol. In: Römpp Online . Georg Thieme Verlag, accessed on May 24, 2014.

[GESTIS-2] ↑ ^a ^b ^c ^d ^e ^f Entry on ethirimol in the GESTIS substance database of the IFA , accessed on February 9, 2017(JavaScript required) .

[CLP_100.041.758-3] Entry on Ethirimol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[unger-4] Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 549 ( limited preview in Google Book search).

[5] Directorate-General for Health and Food Safety of the European Commission: Entry on Ethirimol in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 26, 2016.