François Diederich

from Wikipedia, the free encyclopedia
François Diederich (2016)

François Diederich (born July 9, 1952 in Ettelbrück , Luxembourg ) is professor at the Laboratory for Organic Chemistry at ETH Zurich .

Life

Diederich studied chemistry from 1971 to 1977 at the Ruprecht-Karls-Universität Heidelberg . He then completed his dissertation with Heinz A. Staab at the Max Planck Institute for Medical Research in Heidelberg and received his doctorate in 1979 from Heidelberg University . He succeeded in the first synthesis of Kekulen with HA Staab, a ring made up of 12 benzene rings. After a postdoctoral stay at the University of California, Los Angeles (UCLA) with Orville L. Chapman from 1979 to 1981, he took up a position as a research assistant at the MPI for Medical Research in Heidelberg.

After his habilitation at the University of Heidelberg in 1985, he was appointed to UCLA, where he was appointed Full Professor of Organic and Bioorganic Chemistry in 1989. Since 1992 he has been a full professor of organic chemistry at the Laboratory for Organic Chemistry at ETH Zurich. On July 31, 2017, Diederich retired and remains as a research professor at ETH Zurich. In 2019 he was made an honorary member of the Society of German Chemists (GDCh).

Kekulen

Work areas

  • Molecular recognition in chemistry and biology.
  • Modern medicinal chemistry : molecular recognition studies with biological receptors and structure-based design of non-peptide enzyme inhibitors (focus on anti- malarial agents).
  • Supramolecular nanosystems and nanostructured surfaces.
  • Advanced materials based on carbon-rich acetylenic building blocks: new organic super-acceptors and their inter- and intramolecular charge-transfer complexes , optoelectronic materials for electronic circuits, chiral macrocyclic and acyclic allenoacetylenes, amplification and transfer of molecular chirality to the macroscopic level.

The group's work in these areas is fueled by synthetic incentives and makes use of contemporary synthetic and physical-organic methods.

Selection of important publications

  • F. Diederich, K. Dick: A New Water-Soluble Macrocyclic Host of the Cyclophane Type: Host-Guest Complexation with Aromatic Guests in Aqueous Solution and Acceleration of the Transport of Arenes Through an Aqueous Phase , J. Am. Chem. Soc. 1984, 106, 8024-8036, DOI: 10.1021 / ja00338a005 .
  • DB Smithrud, TB Wyman, F. Diederich: Enthapically Driven Cyclophane Arene Inclusion Complexation - Solvent-Dependent Calorimetric Studies , J. Am. Chem. Soc. 1991, 113, 5420-5426, DOI: 10.1021 / ja00014a038 .
  • R. Ettl, I. Chao, F. Diederich, RL Whetten: Isolation of D2-C76: A Chiral Allotrope of Carbon , Nature 1991, 353, 149-153, DOI: 10.1038 / 353149a0 .
  • L. Isaacs, RF Haldimann, F. Diederich: Tether-Directed Remote Functionalization of Buckminsterfullerene: Regiospecific Hexaadduct Formation , Angew. Chem. Int. Ed. 1994, 33, 2239-2342, DOI: 10.1002 / anie.199423391 .
  • JA Olsen, DW Banner, P. Seiler, U. Obst Sander, A. D'Arcy, M. Stihle, K. Müller, F. Diederich: A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity / Fluorophobicity of an Enzyme Active Site : Evidence for C – F ... C = O Interactions , Angew. Chem. Int. Ed. 2003, 42, 2507-2511, DOI: 10.1002 / anie.200351268 .
  • R. Paulini, K. Müller, F. Diederich: Orthogonal Multipolar Interactions in Structural Chemistry and Biology , Angew. Chem. Int. Ed. 2005, 44, 1788-1805, DOI: 10.1002 / anie.200462213 .
  • K. Müller, C. Fäh, F. Diederich: Fluorine in Pharmaceuticals: Looking beyond Intuition , Science 2007, 317, 1881–1886, DOI: 10.1126 / science.1131943 .
  • LA Hardegger, B. Kuhn, B. Spinnler, L. Anselm, R. Ecabert, M. Stihle, B. Gsell, T. Thoma, J. Diez, J. Benz, J.-M. Plancher, G. Hartmann, DW Banner, W. Haap, F. Diederich: Systematic Investigation of Halogen Bonding in Protein-Ligand Interactions , Angew. Chem. Int. Ed. 2011, 50, 314-318, DOI: 10.1002 / anie.201006781 .
  • O. Dumele, B. Schreib, U. Warzok, N. Trapp, CA Schalley, F. Diederich: Halogen-Bonded Supramolecular Capsules in the Solid State, in Solution, and in the Gas Phase , Angew. Chem. Int. Ed. 2017, 56, 1152–1157, DOI: 10.1002 / anie.201610884 .
  • C. Gropp, N. Trapp, F. Diederich: Alleno-Acetylenic Cage (AAC) Receptors - Chiroptical Switching and Enantioselective Complexation of trans-1,2-Dimethylcyclohexane in a Diaxial Conformation , Angew. Chem. Int. Ed. 2016, 55, 14444–14449, DOI: 10.1002 / anie.201607681 .

Awards

Memberships in scientific academies

Books

  • with PJ Stang and RR Tykwinsky (eds.): Modern Supramolecular Chemistry: Strategies for Macrocycle Synthesis. Wiley-VCH, Weinheim 2008.
  • with PJ Stang and RR Tykwinski (eds.): Acetylene Chemistry. Wiley-VCH, Weinheim 2004.
  • with A. de Meijere (Ed.): Metal-Catalyzed Cross-Coupling Reactions II. Wiley-VCH, Weinheim 2004.
  • with PJ Stang (Ed.): Templated Organic Synthesis. Wiley-VCH, Weinheim 1999.
  • with H. Künzer: Recent Trends in Molecular Recognition. Springer, Berlin 1998.
  • with PJ Stang (Ed.): Metal-Catalyzed Cross-Coupling Reactions. Wiley-VCH, Weinheim 1998.
  • with PJ Stang (Ed.): Modern Acetylene Chemistry. VCH, Weinheim 1995.

Web links

Individual evidence

  1. ^ Biographical data, publications and academic family tree of François Diederich at academictree.org, accessed on January 29, 2018.
  2. ^ François Diederich, Heinz A. Staab: Benzenoidversus Annulenoid Aromaticity: Synthesis and Properties of Kekulene. In: Angewandte Chemie International Edition. Volume 17, 1978, pp. 372-374.
  3. ↑ Member entry of François Diederich (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on July 4, 2016.
personal data
SURNAME Diederich, François
BRIEF DESCRIPTION Luxembourg chemist
DATE OF BIRTH July 9, 1952
PLACE OF BIRTH Ettelbruck , Luxembourg