Hematoporphyrin

Structural formula
Structural formula without specifying the stereochemistry
General
Surname	Hematoporphyrin
other names	Hematoporphyrin IX 7,12-bis (1-hydroxyethyl) -2,8,13,17-tetramethyl-21 H , 23 H -porphine-2,18-dipropionic acid
Molecular formula	C 34 H 38 N 4 O 6
Brief description	purple powder
External identifiers / databases
CAS number 14459-29-1 EC number 238-450-7 ECHA InfoCard 100.034.939 PubChem 11103 Wikidata Q908742
properties
Molar mass	598.69 g mol −1
Physical state	firmly
Melting point	172-173 ° C
safety instructions
GHS labeling of hazardous substances no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
Toxicological data	307 mg kg −1 ( LD 50 ,  mouse ,  iv )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Hematoporphyrin , also Haematoporphyrin , ( English : Hematoporphyrin) is formed by the acidic hydrolysis of hemoglobin . The protein chains are split off and the iron (II) ion is removed. In addition, the two vinyl groups are hydrated , making hematoporphyrin an iron-free heme .

properties

Hematoporphyrin differs from protoporphyrin IX in that the two vinyl groups have been converted into hydroxyethyl residues as a result of the addition of water. Since hydration is not stereospecific, hematoporphyrin consists of four stereoisomers .

use

• Detection of blood in the stool ( hematoporphyrin test , guaiac test )
• Photosensitization of tumors ( photodynamic therapy - PDT)
• Antidepressant since the 1920s

Individual evidence

1. ↑ ^{a b} Data sheet hematoporphyrin, ≥ 55% (HPLC) from Sigma-Aldrich , accessed on November 4, 2016 ( PDF ).
2. ↑ ^{a b} Entry on hematoporphyrin in the ChemIDplus database of the United States National Library of Medicine (NLM) .
3. ↑ ^{a b} entry on hematoporphyrin. In: Römpp Online . Georg Thieme Verlag, accessed on June 15, 2014.