Hartmuth C. Kolb
Hartmuth Christian Kolb (born August 10, 1964 ) is a German chemist . He is considered one of the founders of click chemistry .
Life
After graduating from high school in Marsberg in 1983, Kolb studied at the University of Hanover . He was as an academic student of Steven Ley at Imperial College London with a thesis on preparative organic chemistry (Synthesis of the decalin fragment of azadirachtin ) PhD . He worked as a postdoctoral fellow with Barry Sharpless at the Scripps Research Institute in La Jolla , California . He then worked in the research department of Ciba-Geigy in Basel from 1993 to 1997 before moving to a managerial position at the Coelacanth Corporation in Princeton , New Jersey , founded by Sharpless and A. Bader . Coelacanth was eventually bought out by Lexicon Pharmaceuticals .
In 2002 Kolb received a professorship (associate professor) in the chemistry department of the Scripps Research Institute. Kolb later received a professorship at the University of California, Los Angeles .
In 2004, Kolb returned to the industry and became vice president of the Molecular Imaging Biomarker Research department at Siemens Healthcare in Culver City , California. In 2013 Siemens sold two of the substances developed there to Eli Lilly and Company . At the same time, Kolb joined Avid Radiopharmaceuticals in Philadelphia , Pennsylvania , a subsidiary of Eli Lilly and Company, as vice president of research .
Kolb also acts as managing director of a manufacturer of flavors for animal feed in his hometown Marsberg.
Act
Together with Barry Sharpless, Kolb developed the concept of click chemistry , an approach to simplify syntheses by concentrating on a few chemical reactions that also occur similarly in nature. The associated scientific publication Click chemistry: diverse chemical function from a few good reactions was cited more than eleven thousand times (as of 2018) . Piston refined the method in which it it as in-situ -click chemistry with methods of the microfluidic combined (see chip laboratory ). This makes it particularly easy to synthesize new inhibitors for various enzymes . Kolb's recent work deals with the synthesis of new tracers for positron emission tomography (for example for the detection of the tau protein in Alzheimer's disease ) and with the clinical testing of these tracers.
literature
- Hartmuth C. Kolb, MG Finn and K. Barry Sharpless : Click chemistry: diverse chemical functionality with a handful of good reactions. In: Angewandte Chemie . Volume 113, No. 11, 2001, pp. 2057-2075, doi : 10.1002 / 1521-3757 (20010601) 113: 11 <2056 :: AID-ANGE2056> 3.0.CO; 2-W
Web links
- Profile on LinkedIn
- Hartmuth Kolb presents the results of his investigations: Tau protein in Alzheimer's disease in positron emission tomography (youtube, English)
Individual evidence
- ↑ Life data, publications and academic family tree of Hartmuth C. Kolb at academictree.org, accessed on February 24, 2018.
- ↑ Lilly Acquires Novel Tau Tangle Diagnostic Program to Bolster Alzheimer's Disease Research and Development. Press release of April 17, 2013 at Eli Lilly and Company (lilly.mediaroom.com); Retrieved November 8, 2013
- ↑ Dr. Ernst Kolb GmbH, Marsberg - Imprint (drkolb-aromen.de); Retrieved November 10, 2013
- ↑ Quotations from Google Scholar ; Retrieved November 9, 2013
personal data | |
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SURNAME | Kolb, Hartmuth C. |
ALTERNATIVE NAMES | Kolb, Hartmuth Christian (full name) |
BRIEF DESCRIPTION | German chemist, founder of click chemistry |
DATE OF BIRTH | August 10, 1964 |