Hartmuth C. Kolb

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Hartmuth Christian Kolb (born August 10, 1964 ) is a German chemist . He is considered one of the founders of click chemistry .

Life

After graduating from high school in Marsberg in 1983, Kolb studied at the University of Hanover . He was as an academic student of Steven Ley at Imperial College London with a thesis on preparative organic chemistry (Synthesis of the decalin fragment of azadirachtin ) PhD . He worked as a postdoctoral fellow with Barry Sharpless at the Scripps Research Institute in La Jolla , California . He then worked in the research department of Ciba-Geigy in Basel from 1993 to 1997 before moving to a managerial position at the Coelacanth Corporation in Princeton , New Jersey , founded by Sharpless and A. Bader . Coelacanth was eventually bought out by Lexicon Pharmaceuticals .

In 2002 Kolb received a professorship (associate professor) in the chemistry department of the Scripps Research Institute. Kolb later received a professorship at the University of California, Los Angeles .

In 2004, Kolb returned to the industry and became vice president of the Molecular Imaging Biomarker Research department at Siemens Healthcare in Culver City , California. In 2013 Siemens sold two of the substances developed there to Eli Lilly and Company . At the same time, Kolb joined Avid Radiopharmaceuticals in Philadelphia , Pennsylvania , a subsidiary of Eli Lilly and Company, as vice president of research .

Kolb also acts as managing director of a manufacturer of flavors for animal feed in his hometown Marsberg.

Act

Together with Barry Sharpless, Kolb developed the concept of click chemistry , an approach to simplify syntheses by concentrating on a few chemical reactions that also occur similarly in nature. The associated scientific publication Click chemistry: diverse chemical function from a few good reactions was cited more than eleven thousand times (as of 2018) . Piston refined the method in which it it as in-situ -click chemistry with methods of the microfluidic combined (see chip laboratory ). This makes it particularly easy to synthesize new inhibitors for various enzymes . Kolb's recent work deals with the synthesis of new tracers for positron emission tomography (for example for the detection of the tau protein in Alzheimer's disease ) and with the clinical testing of these tracers.

literature

Web links

  • Profile on LinkedIn
  • Hartmuth Kolb presents the results of his investigations: Tau protein in Alzheimer's disease in positron emission tomography (youtube, English)

Individual evidence

  1. ↑ Life data, publications and academic family tree of Hartmuth C. Kolb at academictree.org, accessed on February 24, 2018.
  2. ↑ Lilly Acquires Novel Tau Tangle Diagnostic Program to Bolster Alzheimer's Disease Research and Development. Press release of April 17, 2013 at Eli Lilly and Company (lilly.mediaroom.com); Retrieved November 8, 2013
  3. ↑ Dr. Ernst Kolb GmbH, Marsberg - Imprint (drkolb-aromen.de); Retrieved November 10, 2013
  4. ↑ Quotations from Google Scholar ; Retrieved November 9, 2013
personal data
SURNAME Kolb, Hartmuth C.
ALTERNATIVE NAMES Kolb, Hartmuth Christian (full name)
BRIEF DESCRIPTION German chemist, founder of click chemistry
DATE OF BIRTH August 10, 1964