Idoxuridine
Structural formula | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
![]() |
||||||||||||||||||||||
General | ||||||||||||||||||||||
Non-proprietary name | Idoxuridine | |||||||||||||||||||||
other names |
|
|||||||||||||||||||||
Molecular formula | C 9 H 11 IN 2 O 5 | |||||||||||||||||||||
Brief description |
White dust |
|||||||||||||||||||||
External identifiers / databases | ||||||||||||||||||||||
|
||||||||||||||||||||||
Drug information | ||||||||||||||||||||||
ATC code | ||||||||||||||||||||||
properties | ||||||||||||||||||||||
Molar mass | 354.10 g · mol -1 | |||||||||||||||||||||
Physical state |
firmly |
|||||||||||||||||||||
Melting point |
190 ° C |
|||||||||||||||||||||
solubility |
poor in water (1.6 g l −1 at 20 ° C) |
|||||||||||||||||||||
safety instructions | ||||||||||||||||||||||
|
||||||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Idoxuridine ( 2′-deoxy-5-iodo-uridine ) is a biochemical analogue of the nucleoside uridine . It consists of 5-ioduracil and deoxyribose .
It is used as an antiviral (e.g. Virunguent ® ) against herpes simplex viruses . According to Coster et al. it is said to have a similar effectiveness as acyclovir . Idoxurin acts as an antagonist of thymidine in the DNA synthesis of viruses .
Individual evidence
- ↑ a b c d data sheet (+) - 5-Iodo-2'-deoxyuridine, 98% from AlfaAesar, accessed on December 7, 2019 ( PDF )(JavaScript required) .
- ↑ Data sheet Idoxuridine from Acros, accessed on December 19, 2019.
- ↑ DJ Coster, KR Wilhelmus, R. Michaud, BR Jones: A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis , in: Br J Ophthalmol. , 1980 , 64 (10), pp. 763-765 ( PMC 1043812 (free full text); PMID 7000170 ).