Indoramine

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Structural formula
Structure of indoramine
General
Non-proprietary name Indoramine
other names

N - {1- [2- (Indol-3-yl) ethyl] -4-piperidyl} benzamide ( IUPAC )

Molecular formula C 22 H 25 N 3 O
External identifiers / databases
CAS number
  • 26844-12-2
  • 38821-52-2 hydrochloride
EC number 248-041-5
ECHA InfoCard 100,043,659
PubChem 33625
ChemSpider 31014
DrugBank DB08950
Wikidata Q408963
Drug information
ATC code

C02 CA02

Drug class

Antihypertensive drugs

Mechanism of action

α 1 -adrenoceptor - antagonist

properties
Molar mass 347.45 g · mol -1
Physical state

firmly

Melting point

209 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 302-315-319-335
P: 261-305 + 351 + 338
Toxicological data

1800 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Indoramin is an α 1 receptor blockers ( alpha blockers ), which as a drug for the treatment of high blood pressure is used ( antihypertensive ).

effect

The effect of indoramine is based on the expansion of the blood vessels .

Side effects

Among other things, there may be a sharp drop in blood pressure with dizziness and headaches at the beginning of treatment with indoramine. The orthostatic hypotension is characteristic of alpha blockers.

Trade names

Indoramine is available in Germany under the trade name Wydora ® .

literature

  • HPT Ammon (Ed.): Hunnius Pharmaceutical Dictionary . 9th edition. Walter de Gruyter, Berlin a. New York 2004.

Individual evidence

  1. ↑ a b Entry on indoramine in the ChemIDplus database of the United States National Library of Medicine (NLM) .
  2. ↑ a b data sheet Indoramin hydrochloride from Sigma-Aldrich , accessed on April 5, 2011 ( PDF ).