Ionomycin
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| Surname | Calcium (4 R , 6 S , 8 S , 10 Z , 12 R , 14 R , 16 E , 18 R , 19 R , 20 S , 21 S ) -19,21-dihydroxy-22 - {(2 S , 2 ' R , 5 S , 5' S ) -5 '- [(1 R ) -1-hydroxyethyl] -2,5'-dimethyloctahydro-2,2'-bifuran-5-yl} -4,6,8, 12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate | ||||||||||||||||||
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Ionomycin ( calcium salt ) |
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| Molecular formula | C 41 H 70 CaO 9 | ||||||||||||||||||
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| Molar mass | 747.07 g • mol −1 | ||||||||||||||||||
| Physical state |
firmly |
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| Melting point |
204-206 ° C |
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||||||||
Ionomycin is a substance produced by the bacterium Streptomyces conglobatus , which belongs to the group of ionophores . As such, ionomycin is able to transport calcium ions through biological membranes , which is why it is used in research.
Various effects have been described:
- Ionomycin triggered the cell death of nerve cells in the embryonic cerebral cortex ( apoptotic degeneration of embryonic cortical neurons).
- It influenced the intracellular production of the cytokines interferon , perforin , interleukin-2 and interleukin 4 , which play an important role in inflammatory processes .
Ionomycin is commercially available as a free acid or as a calcium salt.
Web links
- Safety data sheet for the ionomyin calcium salt (PDF; 57 kB) from Cellsignal
- Information page of the company Tocris Bioscience (USA)
Individual evidence
- ↑ a b c Entry on Ionomycin. In: Römpp Online . Georg Thieme Verlag, accessed on June 16, 2014.
- ↑ Applichem: ionomycin - calcium salt BioChemica.
- ↑ a b c d e Information page from Fermentek Ltd. ( Memento of the original from January 27, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (Israel)
- ↑ a b Data sheet Ionomycin calcium salt from Streptomyces conglobatus from Sigma-Aldrich , accessed on April 5, 2011 ( PDF ).
- ↑ Serum chemokines and expression of chemokine receptors in Bechterew's disease (using ionomycin) (PDF; 995 kB).
- ↑ Julia Albrecht: The influence of MHC compatibility on the suppressive activity of natural CD4 + CD25 + regulatory T cells (using ionomycin) (PDF; 5.36 MB).
