Isosorbide mononitrate

Structural formula
General
Non-proprietary name	Isosorbide mononitrate
other names	(3 S , 3a R , 6 R , 6a S ) -6-Nitrooxyhexahydrofuro [3,2- b ] furan-3-ol ( IUPAC )
Molecular formula	C 6 H 9 NO 6
External identifiers / databases
EC number	240-197-2
ECHA InfoCard	100.036.527
PubChem	27661
ChemSpider	25736
DrugBank	DB01020
Wikidata	Q423401
Drug information
ATC code	C01 DA14
Drug class	Vasodilator
properties
Molar mass	191.14 g · mol -1
Physical state	firmly
Melting point	88-93 ° C
solubility	moderately in water
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 228-302
	P: 210-280-240-241-264-270-301 + 312-330-370 + 378-501
Toxicological data	1771 mg kg −1 ( LD 50 , mouse , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Isosorbide mononitrate is a long-acting nitrate that is used in patients with angina pectoris or heart attack . It is an NO donor that releases nitric oxide through enzymatic metabolism and has a vasodilating effect. So there is a tendency to group blood vessels more into groups of the same size and thereby increase the blood flow, as the vessels are expanded in this way.

Trade names

Monopreparations

Coleb-Duriles (D), Conpin (D), Corangin (D, CH), Elantan (D), Ismo (D), Isomonat (A), Isomonit (D), Monit-Puren (D), Monobeta (D) , Monoclair (D), Monolong (D), Mono Mack (D, A), Monoket (A), Mononitrat (D), Myocardon (A), Olicardin (A), Turimonit (D), numerous generics (D, A )

Individual evidence

↑ ^a ^b ^c data sheet isosorbide mononitrate from Acros, accessed on February 20, 2010.
↑ ^a ^b Data sheet Isosorbide mononitrate, 98 +% from AlfaAesar, accessed on November 1, 2016 ( PDF )(JavaScript required) .
↑ Red List online, as of September 2009.
↑ AM comp. d. Switzerland, as of September 2009.
↑ AGES-PharmMed, as of September 2009.

[acros-1] ta sheet isosorbide mononitrate from Acros, accessed on February 20, 2010.

[Alfa-2] Data sheet Isosorbide mononitrate, 98 +% from AlfaAesar, accessed on November 1, 2016 ( PDF )(JavaScript required) .

[3] Red List online, as of September 2009.

[4] AM comp. d. Switzerland, as of September 2009.

[5] AGES-PharmMed, as of September 2009.