Ivar Karl Ugi

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Ivar Karl Ugi (born September 5, 1930 in Arensburg on the island of Saaremaa in Estonia ; † September 29, 2005 in Munich ) was a German-Estonian chemist who made important contributions to organic chemistry , especially to multi-component reactions . Such a reaction was named after him the Ugi reaction .

Life

Ivar Ugi grew up in Estonia and came to Germany in 1941, where he began studying chemistry at the University of Tübingen in 1949 . There he joined the Derendingia fraternity in Tübingen in 1950 . From 1951 to 1954 he studied until his graduation as Dr. rer. nat. at the Ludwig Maximilians University in Munich , his doctoral supervisor was Rolf Huisgen . Ugi completed his habilitation in Munich in 1960. Two years later he worked with some success at Bayer AG in Leverkusen (1962 to 1968), where he rose to become Director of Central Research and Chairman of the Commission for Basic Research, but then turned back to academic research.

Ugi spent three years at the University of Southern California in Los Angeles as professor of chemistry (1968 to 1971), after which he took over the chair I for organic chemistry from Friedrich Weygand at the Technical University of Munich . Ugi was chairman of the first international conference for computers in chemical research and education ( International Conference on Computers in Chemical Research and Education , ICCCRE) in Garmisch-Partenkirchen 1985. In October 2000 he co-organized the first conference for multicomponent reactions ( First International Conference on MultiComponent Reactions , MCR 2000). In 1987 Ugi was admitted to the Royal Swedish Academy of Sciences , in 1990 to the Estonian Academy of Sciences and in 1994 as an honorary member of the New York Academy of Sciences . From 1999 until his death in 2005, he also remained associated with the Technical University of Munich as an emeritus.

research

With over 400 publications, Ugi was an extremely productive researcher, with the work on the Ugi reaction standing out in particular. In this multicomponent reaction, the so-called one - pot reaction of a ketone or aldehyde , an amine , an isocyanide and a carboxylic acid , bis-amides are formed , which can be used for a variety of syntheses. The extension of the Ugi reaction is sometimes also referred to as Ugi chemistry in specialist circles . The basic work on the multicomponent reaction served as a starting point for further work. Ben List and Jürgen Martens ( University of Oldenburg ) developed further variants of the Ugi reaction.

He also explored the Arylpentazole, chemical libraries, chiral ferrocene , reaction mechanisms and preparation of organic phosphorus compounds , esters of Fluorocarbonsäuren, kinetics of reactions mathematical theories of stereochemistry and mathematical models of the chemistry with the help of computational chemistry . For this purpose, Ugi developed the idea of ​​algebraic chemistry with his friend, mathematician James Dugundji (1919–1985), which uses chemical starting materials in a reaction, such as numbers in an algebraic equation.

Awards

For the discovery of his four-component reaction and the development of mathematical models for chemistry, Ugi was awarded the chemistry prize of the Academy of Sciences in Göttingen in 1964. In 1988 he received the Philip Morris Research Prize Challenge Future Prize and in 1992 the Emil Fischer Medal of the Society of German Chemists for the further development of computational chemistry and multi-component reactions. The first Ugi Dugundji Medal was awarded to him in 1995 for his fundamental work on the application of mathematics in chemistry by the Second International Symposium on Knowledge Acquisition in Auburn (Alabama, USA). In October 1999 he received the Max Bergmann Medal for promoting peptide chemical research .

Fonts

  • The α-Addition of Immonium Ions and Anions to Isonitriles Accompanied by Secondary Reactions. In: Angew. Chem. Int. Ed. Engl. 1 (1), 1962, pp. 8-21.

swell

Individual evidence

  1. ↑ Membership directory of the Derendingia fraternity in Tübingen.  1967, master roll no. 961
  2. ^ Louis Fieser, Mary Fieser: Organische Chemie , Verlag Chemie Weinheim, 2nd edition, 1972, p. 1437, ISBN 3-527-25075-1 .
  3. ↑ Alexander Dömling: Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry , Chemical Reviews 106 ( 2006 ) 17-89.

Web links

personal data
SURNAME Ugi, Ivar Karl
BRIEF DESCRIPTION German-Estonian chemist
DATE OF BIRTH 5th September 1930
PLACE OF BIRTH Arensburg on Saaremaa Island in Estonia
DATE OF DEATH September 29, 2005
Place of death Munich