Joan Massagué Solé
Joan Massagué Solé (born April 30, 1953 in Barcelona ) is a Spanish pharmacologist and cancer researcher.
biography
Joan Massagué Solé was born in Barcelona in 1953 . He studied pharmacy and received his PhD in biochemistry from the Universidad de Barcelona in 1978 . While working at Brown University (since 1982) in Providence , Rhode Island , USA, he discovered the structure of the insulin receptor . He later worked as a professor of biochemistry at the University of Massachusetts . In 1989 he became head of the Cell Biology and Genetics Department at Memorial Sloan-Kettering Cancer Center in New York, where he has headed the Cancer Biology and Genetics Program since 2003. He is a researcher for the Howard Hughes Medical Institute . Joan Massagué is Deputy Director of the Institut de Recerca Biomèdica (IRB Barcelona), where he heads the MetLab research group , which has several projects investigating the cell proliferation of tumor cells and metastases .
Research projects
Massagué's research interests focused primarily on the mechanisms of information transmission that are necessary for normal tissue development and that get out of control in cancer. This is the case, for example, with TGF-β ( transforming growth factor β), a cytokine that plays an important role in inflammatory processes and regulates cell division during embryonic development .
meaning
Massagué is one of the foremost researchers in the field of the regulation of cell division and metastasis in cancer, the author of more than 250 scientific articles on these topics and one of the fifty most cited scientists in all disciplines over the past 20 years (and among the five most cited Biochemists). His research results are central to deciphering the mechanisms that stop cell division, i.e. the process that, when out of control, leads to tumor formation. His work made it possible to identify the genes that control the metastasis of tumor cells to other organs in breast cancer , a discovery that opens up new research prospects.
Massagué is a member of the American Academy of Arts and Sciences (1999), the National Academy of Sciences (2000), the European Molecular Biology Organization and the Spanish Royal Academies of Medicine and Pharmacy (Reales Academias Españolas de Medicina y Farmacia). He has received numerous awards, including the Keith R. Porter Lecture 2000, the Premio Fundación BBVA Fronteras del Conocimiento for Biomedicine in 2008, the Prince of Asturias Prize in the science and technology category in 2004, the Premio Nacional de Investigación Rey Don Juan Carlos I and the Howard Taylor Ricketts Award . In 2012 Solé received the Pasarow Award for Cancer Research. In 2015 he was awarded the Charles Rodolphe Brupbacher Prize for Cancer Research .
Fonts (selection)
- Joan Massagué Solé: Regulació hormonal del metabolisme hepàtic del glicògen: efectes del glucagó, l'epinefrina i la insulina. Dissertation , Universidad de Barcelona , 1978
- Joan Massagué Solé, James M. Roberts, Rik Derynck, Erwin F. Wagner: Cell multiplication. Current Biology Ltd., 1995
- Joan Massagué Solé: Mechanisms of cytostasis and metastasis. In: Anales de la Real Academia Nacional de Medicina (Madr). Volume 121, No. 4, 2004, pp. 559–571, PMID 15997585 ( digital copy ; PDF; 7.1 MB)
- Joan Massagué Solé: Actes d'urbanitat i terrorisme cellular: de la citostasis a la metàstasis. Publishing house Reial Acadèmia de Farmàcia de Catalunya, 2006
Web links
| personal data | |
|---|---|
| SURNAME | Massagué Solé, Joan |
| BRIEF DESCRIPTION | Spanish pharmacologist and cancer researcher |
| DATE OF BIRTH | April 30, 1953 |
| PLACE OF BIRTH | Barcelona |