Johannes Kornhuber

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Johannes Kornhuber

Johannes Kornhuber (born September 11, 1959 in Freiburg im Breisgau ) is a German psychiatrist and psychotherapist . He is professor of psychiatry and psychotherapy at the Friedrich-Alexander-Universität Erlangen-Nürnberg and director of the Psychiatric and Psychotherapeutic Clinic at the University Hospital Erlangen .

Life

Johannes Kornhuber studied medicine at the University of Ulm . He was awarded a Dr. med. doctorate and later worked as a scholarship holder of the German Research Foundation at the Psychiatric University Clinic in Würzburg . He qualified as a professor at the University of Würzburg in 1992 in psychiatry and psychotherapy. From 1996 he headed the gerontopsychiatry department at the Psychiatric University Clinic in Göttingen as a major professor ; from 1998 he was also senior physician and deputy director of the clinic. Since 2000 he has been professor for psychiatry and psychotherapy and director of the psychiatric and psychotherapeutic university clinic at the Friedrich-Alexander-Universität Erlangen-Nürnberg .

Johannes Kornhuber is married and has two children. He is the son of the neurologist Hans Helmut Kornhuber .

plant

Kornhuber contributed to the understanding of the biological basis of depression , schizophrenia , addictions and dementia disorders and discovered new mechanisms of action of psychotropic drugs.

The description of the mechanism of action of memantine provided an important basis for its worldwide approval as an antidementia drug . When he continued to work with memantine and other psychotropic drugs , Kornhuber found a high concentration of the substances in human brain tissue, among other things. a. due to uptake in acidic intracellular areas. The high accumulation in the brain tissue allows a better understanding of both the delayed onset of action of antidepressants and neuroleptics as well as the prolonged effects after their discontinuation. These considerations suggested new sites of action for psychotropic drugs within the acidic intracellular areas. One of these sites of action is the intra-lysosomal ceramide- forming enzyme acid sphingomyelinase . Antidepressants inhibit this enzyme and develop their effect through it. The effect of neuroleptics can also be partly explained by their accumulation in acidic synaptic vesicles . In the field of addictions, Kornhuber is investigating the formative effects of prenatal testosterone on the developing brain. He participated in the development of the glutamate hypothesis of schizophrenia .

Kornhuber is involved in national collaborative research projects, including a. involved in the dementia competence network, the research network for mental illnesses, a research network for the prevention of addictions and in the development of the current guidelines on dementia. In clinical care, he advocates multimodal treatment.

Awards

  • Science awards
    • Science Award of the German Society for Psychiatry and Neurology (1990)
    • Organon Prize of the German Society for Biological Psychiatry (1990)
    • Rafaelsen Award of the Collegium Internationale Neuro-Psychopharmacologicum (1994)
    • Burda Prize 1994 the Senator Dr. Franz Burda Foundation (1995)
    • Klaesi Prize of the Swiss Academy of Medical Sciences (1995)
    • AGNP Prize for Research in Psychopharmacology (1999)
    • Honorary Prize - German Prize for Pain Research and Pain Therapy (2000)
    • Prize "ZukunftErhabenNRW" The university competition 2011 3rd prize (together with Jens Wiltfang, Manuel Maler et al .; 2011)
    • Annika Liese Prize (together with Erich Gulbins) (2014)
    • Wilhelm Feuerlein Research Award 2016 (together with Bernd Lenz and Christian P. Müller)
  • Other prices
    • Awards for "good teaching" in human medicine, University of Erlangen (2006, 2010, 2013, 2014, 2015)
    • Renate Wittern Sterzel Prize (Equal Opportunities Prize), University of Erlangen (2016, together with Ingrid Artus, Stefan Kerber-Clasen and Judith Holland)

Fonts (selection)

  • WD Oswald, U Lehr, C Sieber, J Kornhuber (eds.): Gerontology. Basic medical, psychological and social science terms . Kohlhammer, Stuttgart 2006, ISBN 978-3-17-018633-0 .
  • M Stemmler, J Kornhuber: Dementia diagnostics . Hogrefe, Göttingen 2018, ISBN 978-3-8017-2760-4 .

Web links

Individual evidence

  1. ↑ Psychiatric and Psychotherapeutic Clinic , University Hospital Erlangen
  2. ^ J Kornhuber, J Bormann et al .: Memantine displaces [ 3 H] MK-801 at therapeutic concentrations in postmortem human frontal cortex . In: European Journal of Pharmacology . 166, 1989, pp. 589-590, PMID 2680528
  3. ↑ J Kornhuber, A Schultz et al .: Persistence of haloperidol in human brain tissue . In: American Journal of Psychiatry . 156, 1999, pp. 885-890, PMID 10360127
  4. ^ J Kornhuber, H Weigmann et al .: Region specific distribution of levomepromazine in the human brain . In: Journal of Neural Transmission . 113, 2006, pp. 387-397, PMID 15997416
  5. ^ J Kornhuber, G Quack et al .: Therapeutic brain concentration of the NMDA receptor antagonist amantadine . In: Neuropharmacology . 34, 1995, pp. 713-721, PMID 8532138
  6. ↑ S. Trapp, G Rosania, RW Horobin, J grain Huber: Quantitative modeling of selective lysosomal targeting for drug design . In: European Biophysics Journal . 37, 2008, pp. 1317-1328, PMID 18504571
  7. ^ J Kornhuber, W Retz, P. Riederer: Slow accumulation of psychotropic substances in the human brain. Relationship to therapeutic latency of neuroleptic and antidepressant drugs? In: Journal of Neural Transmission . Suppl. 46, 1995, pp. 311-319, PMID 8821068
  8. ↑ J grain Huber, P Tripal et al .: Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model . In: Journal of Medicinal Chemistry . 51, 2008, pp. 219-237, PMID 18027916
  9. ↑ J Kornhuber, P Tripal et al .: Functional inhibitors of acid sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications . In: Cellular Physiology and Biochemistry . 26, 2010, pp. 9-20, PMID 20502000
  10. ↑ E Gulbins, M Palmada et al .: Acid sphingomyelinase / ceramide system mediates effects of antidepressant drugs . In: Nature Medicine . 19, 2013, pp. 934-938, PMID 23770692
  11. ↑ J Kornhuber, CP Müller et al .: The ceramide system as a novel antidepressant target . In: Trends in Pharmacological Sciences . 35, 2014, pp. 293-304, PMID 24793541
  12. ↑ CH Tischbirek, EM Wenzel et al .: Use-dependent inhibition of synaptic transmission by secretion of intravesicularly accumulated weak base antipsychotic drugs . In: Neuron . 74, 2012, pp. 830-844, PMID 22681688
  13. ^ B Lenz, CP Müller et al .: Sex hormone activity in alcohol addiction - integrating organizational and activational effects . In: Progress in Neurobiology . 96, 2012, pp. 136-163, PMID 22115850
  14. ↑ J Kornhuber, G Erhard et al .: Low digit ratio 2D: 4D in alcohol dependent patients . In: PLOS ONE . 6, 2011, p. E19332, PMID 21547078
  15. ↑ J grain Huber, EM Zenses et al .: Low digit ratio 2D: 4D associated with video game addiction . In: PLOS ONE . 8, 2013, p. E79539, PMID 24236143
  16. ↑ J Kornhuber, EG Fischer: Glutamic acid diethyl ester induces catalepsy in rats. A new model for schizophrenia? In: Neuroscience Letters . 34, 1982, pp. 325-329, PMID 6891756
  17. ↑ J Kornhuber, F Mack-Burkhardt et al .: [ 3 H] MK-801 binding sites in postmortem brain regions of schizophrenic patients . In: Journal of Neural Transmission . 77, 1989, pp. 231-236, PMID 2547892
  18. Jump up ↑ J Kornhuber, M Weller: Psychotogenicity and NMDA receptor antagonism: implications for neuroprotective pharmacotherapy . In: Biological Psychiatry . 41, 1997, pp. 135-144, PMID 9018383
  19. ↑ Competence network dementias
  20. Jump up ↑ J Kornhuber, K Schmidtke et al .: Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network . In: Dementia and Geriatric Cognitive Disorders . 27, 2009, pp. 404-417, PMID 19339779
  21. ^ Research network for mental illnesses
  22. ↑ IMAC-MIND
  23. ↑ S3 guideline dementias ( memento of the original from 23 September 2015 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF)  @1@ 2Template: Webachiv / IABot / www.dgppn.de
  24. ↑ Annika Liese Prize 2014
personal data
SURNAME Kornhuber, Johannes
BRIEF DESCRIPTION German psychiatrist and psychotherapist
DATE OF BIRTH September 11, 1959
PLACE OF BIRTH Freiburg in Breisgau