Klaus Wolff

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Klaus Wolff (born December 4, 1935 in Sibiu / Transylvania , † December 20, 2019 ) was an Austrian dermatologist .

Life

After studying medicine at the University of Vienna , training in dermatology at the I. University Dermatology Clinic, and research work at the Mayo Clinic, Rochester , Minnesota , Klaus Wolff was appointed head of the Department of Experimental Dermatology at the University of Vienna Visiting professor at Harvard University , Boston , appointed full professor and head of the Department of Dermatology at Innsbruck University in 1976.

In 1981 he was appointed to the University of Vienna, where Klaus Wolff worked as a full professor and head of the Dermatological University Clinic. He took on an intensive teaching activity with the training of generations of medical students and specialists in dermatology. His research achievements, which led to the clarification of the pathomechanisms of skin diseases and the development of new therapies, are internationally recognized. Under his leadership, the Dermatological University Clinic Vienna achieved a ranking among the five best dermatological university clinics in the world. From October 2004 Klaus Wolff was retired and devoted himself to his patients and the books he edited.

In 1984 Wolff was elected a member of the Leopoldina .

Fonts (selection)

Over 430 scientific publications (original papers, book chapters or overviews) in the fields of clinical dermatology, histopathology, immunology and basic dermatological research (see list of publications)

Books

  • with IM Freedberg, AZ Eisen, KF Austen, LA Goldsmith and SI Katz (eds.): Fitzpatrick's Dermatology in General Medicine. 2nd Edition. 1979, 3rd edition 1987, 4th edition 1993, 5th edition 1999, 6th edition 2003 and Spanish editions (1980, 1988), McGraw-Hill, New York.
  • with RA Johnson and D. Suurmond: Fitzpatrick′s Color Atlas and Synopsis of Clinical Dermatology. 2nd Edition. 1992, 3rd edition 1997, 4th edition 2001, 5th edition 2005, McGraw-Hill, New York. Translations into Italian, German, Spanish, Portuguese, Russian, Greek, Indonesian, French, Korean, Mandarin.
  • with K. Holubar and K. Schmidt: Challenge Dermatology. Austrian Academy of Sciences, Vienna 1993.
  • with RK Winkelmann: Vasculitis. Lloyd & Luke, London 1979.
  • with TB Fitzpatrick, AZ Eisen, IM Freedberg and KF Austen (eds.): Dermatology in General Medicine. Update I, MacGraw Hill, New York 1982.
  • Synopsis and Atlas of Clinical Dermatology. McGraw-Hill, 1993. 2nd edition: Stuttgart 1994, 3rd edition 1997, McGraw-Hill International (UK).

Editor / co-editor

Editorial boards

Research priorities

Scientific achievements (in cooperation with employees of the I. University Dermatology Clinic Vienna, the University Clinic for Dermatology Innsbruck and the University Clinic for Dermatology Vienna):

  1. Cell biology
    • Lysosomal System of the Epidermis (1968–1974)
    • Intercellular space of the epidermis ( glycocalyx , permeability) (1968–1975)
    • Pigment transfer (1971–1973)
    • Langerhans cells (LZ): LZ are not related to melanocytes (1966–1969), LZ are mesenchymal cells (1972) and carry immunological receptors (Fc, C3, Ia antigens) (1977); Inhibition of allogeneic and syngeneic T-cell-activating and antigen-presenting functions of LZ by ultraviolet light (1980–1982);
    • Discovery and characterization of the dendritic Thy – 1 + epidermal cells (1983)
    • Detection of HIV in LZ; LZ are reservoirs for HIV (1987, 1988)
    • Cadherins in Angioneogenesis (1996)
    • Discovery of the endogenous retrovirus MERV I in melanoma (2003)
  2. Immunodermatology
    • First detection of the ultrastructural localization of antibodies and immune complexes in the skin in pemphigus, dermatitis herpetiformis, herpes gestationis , CDLE, SLE (1971–1976)
    • Complement activation on intermediate filaments in the skin (1982)
    • Immunophenotyping in GvHD (1987)
    • Immunophenotyping of histiocytosis X (1988)
    • Class II alloantigen expression in the epidermis (1987)
    • The skin as an immune organ (1985-)
    • Autoantibodies in Erythema multiforme (1995)
    • Lymphocyte Homing in the Skin (SCID Mouse Model) (1996)
    • FcgRII in immune complex vasculitis (1996)
  3. Experimental dermatology
    • Elaboration of a mouse model for erythropoietic protoporphyria (1975, 1976)
    • Experimental induction of "Staphylococcal-induced scalded skin syndrome" in humans (1974)
  4. Clinical dermatology
    • Melanoderma in malignant melanoma (1976)
    • C4 deficiency and lupus erythematosus (1982)
    • "IF-mapping" of antigenic determinants in mechanobullous dermatoses (1981)
    • Generalized atrophic benign epidermolysis bullosa (1982)
    • Vegetating Scarring Pemphigoid (1987)
    • Epiluminescence microscopy (dermoscopy) for early diagnosis of malignant melanoma (1987)
    • Digitized epiluminescence microscopy (1995)
  5. therapy
    • First successful treatment of pemphigus with azathioprine (1969)
    • Co-development of the concept of photochemotherapy for psoriasis and other diseases; Clinic and elaboration of therapy guidelines, clarification of the mechanisms (1975–1985)
    • Retinoid PUVA chemophotochemotherapy (1978)
    • First successful local immunosuppression with macrolides (1996)
    • BCL – 2 antisense therapy for melanoma (1998)
    • Interferon-alpha2a as adjuvant therapy for melanoma
    • Ras antagonist therapy for melanoma (1999)
    • Systemic, skin-targeted therapy (pimecrolimus) 2002
    • First pharmacogenomic study in humans (psoriasis, pimecrolimus) (2002)
    • Cardoprotective effect of peptide Bb15-42 on reperfusion damage, 2005

Honors

  • Marchionini Gold Medal, 1997
  • Stephen Rothman Medal , 1998
  • D. Martin Carter Award, 1998
  • Clarence S. Livingood Lectureship, AAD, 2002
  • Hebra Medal in Gold, 2002
  • Gold Medal ÖGDV, 2003
  • Magister Dermatologiae Hungarorum, 2004

Badge of honor

Honorary doctorates

  • Honorary doctorate (medicine), University of Kiel, 1997
  • Honorary doctorate (medicine), Semmelweis University Budapest, 1999
  • Honorary doctorate (medicine), Lucian Blaga University, Sibiu / Hermannstadt, 2003

Scientific awards

Klaus Wolff scholarship

In 2005, an American patron established the Klaus Wolff Scholarship, which enables young Austrian researchers to train at Harvard University .

Web links

Individual evidence

  1. ^ Medical University of Vienna: MedUni Vienna mourns Klaus Wolff. MedUni Vienna, accessed on December 20, 2019 .
  2. ↑ Member entry by Prof. Dr. Klaus Wolff (with picture) at the German Academy of Sciences Leopoldina , accessed on July 20, 2016.
  3. ↑ List of all decorations awarded by the Federal President for services to the Republic of Austria from 1952 (PDF; 6.9 MB)
personal data
SURNAME Wolff, Klaus
BRIEF DESCRIPTION Austrian dermatologist
DATE OF BIRTH 4th December 1935
PLACE OF BIRTH Sibiu / Transylvania
DATE OF DEATH 20th December 2019