List of top-selling drugs

from Wikipedia, the free encyclopedia

This list contains the drugs with the highest sales .

Worldwide

2018

rank Preparation name Active ingredient (s) Sales in billion USD Sales in billion USD Marketing authorization holder Active ingredient group
1 Humira Adalimumab 19.9 20.47 AbbVie TNF blockers
2 Revlimid Lenalidomide 9.7 9.69 Celgene Immunomodulators
3 Keytruda Pembrolizumab 7.2 7.17 Merck Immunomodulators
4th Herpectin Trastuzumab 7.1 7.05 Roche Cancer immunotherapeutic agents
5 Avastin Bevacizumab 7th 6.92 Roche Antineoplastic agents
6th Rituxan / MabThera Rituximab 6.9 6.82 Roche Antineoplastic agents
7th Opdivo Nivolumab 6.7 7.57 Bristol-Myers Squibb Checkpoint inhibitor
8th Eliquis Apixaban 6.4 9.87 Bristol-Myers Squibb Anticoagulants
9 Prevenar 13 Pneumococcal polysaccharide 5.72 5.80 Pfizer Pneumococcal vaccine
10 Stelara Ustekinumab 5.7 5.25 Johnson & Johnson Interleukin inhibitor
Enbrel Etanercept 7.45 Amgen, Pfizer, Takeda Anti-inflammatory drugs
Xarelto Rivaroxaban 6.85 Bayer, Johnson & Johnson Anticoagulants
Imbruvica Ibrutinib 6.61 AbbVie, Johnson & Johnson Tyrosine Kinase Inhibitors
Eylea Aflibercept 6.55 Bayer, Regeneron Antineoplastic agents
Remicade Infliximab 6.44 Johnson & Johnson, Merck, Mitsubishi Tanabe TNF blockers

2017

rank Preparation name Active ingredient (s) Sales in billion USD Marketing authorization holder Active ingredient group
1 Humira Adalimumab 18,946 AbbVie TNF blockers
2 Enbrel Etanercept 8.262 Amgen , Pfizer, Takeda Anti-inflammatory drugs
3 Eylea Aflibercept 8.26 Bayer, Regeneron Antineoplastic agents
4th Revlimid Lenalidomide 8.187 Celgene Immunomodulators
5 Rituxan / MabThera Rituximab 7.831 Roche Antineoplastic agents
6th Remicade Infliximab 7.83 Johnson & Johnson , Merck, Mitsubishi Tanabe TNF blockers
7th Herpectin Trastuzumab 7.435 Roche Cancer immunotherapeutic agents
8th Eliquis Apixaban 7.395 Roche Anticoagulants
9 Avastin Bevacizumab 7,089 Roche Antineoplastic agents
10 Xarelto v Rivaroxaban 6.590 Bayer, Johnson & Johnson Anticoagulants
11 Opdivo Nivolumab 5.815 Bristol-Myers Squibb , Ono Pharmaceutical Checkpoint inhibitor
12 Lantus Insulin glargine 5.731 Sanofi Antidiabetic drugs
13 Prevenar 13 Pneumococcal polysaccharides 5.601 Pfizer Pneumococcal vaccine
14th Lyrica Pregabalin 5.318 Pfizer , Eisai Anticonvulsants
15th Neulasta Pegfilgrastim 4,553 Amgen , Kyowa Hakko Kirin Immunostimulants

2015

rank Preparation name Active ingredient (s) Sales in billion USD Marketing authorization holder Active ingredient group
1 Humira Adalimumab 16.07 AbbVie TNF blockers
2 Harvoni Ledipasvir and sofosbuvir 9.08 Gilead Sciences Antivirals
3 Enbrel Etanercept 8.87 Amgen Anti-inflammatory drugs
4th Rituxan Rituximab 8.53 Roche Antineoplastic agents
5 Remicade Infliximab 7.83 Johnson & Johnson TNF blockers
6th Revlimid Lenalidomide 6.97 Celgene Immunomodulators
7th Avastin Bevacizumab 6,752 Roche Antineoplastic agents
8th Herpectin Trastuzumab 6.75 Roche Cancer immunotherapeutic agents
9 Lantus Insulin glargine 6.05 Sanofi Antidiabetic drugs
10 Prevenar 13 Pneumococcal polysaccharides 5.72 Pfizer Pneumococcal vaccine

2013

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After compilation at the University of Freiburg.

rank Active ingredient Sales in billion USD Manufacturer Active ingredient group
1 Adalimumab 10.058 AbbVie TNF blockers
2 Fluticasone + salmeterol 9,064 GlaxoSmithKline Corticosteroids + beta-2 sympathomimetics
3 Etanercept 8.096 Amgen TNF blockers
4th Rosuvastatin 8.025 AstraZeneca Statins
5 Infliximab 7.805 Johnson & Johnson , MSD TNF blockers
6th Esomeprazole 7.773 AstraZeneca Proton pump inhibitors
7th Insulin glargine 7.773 Sanofi-Aventis Insulin analogs
8th Aripiprazole 7.697 Bristol-Myers Squibb , Otsuka Atypical neuroleptics
9 Duloxetine 6.373 Eli Lilly and Company Serotonin norepinephrine reuptake inhibitors
10 Rituximab 6.154 Roche Monoclonal Antibodies : CD20
11 Bevacizumab 5.518 Roche Angiogenesis inhibitors
12 Tiotropium bromide 5.256 Boehringer Ingelheim Anticholinergics
13 Trastuzumab 5.064 Roche Monoclonal antibodies : HER2 / neu
14th Pregabalin 5.060 Pfizer Anticonvulsants
15th Glatiramer acetate 4,650 Teva Pharmaceutical Industries Immunomodulators
16 Ranibizumab 4,490 Roche , Novartis Monoclonal Antibodies : VEGF
17th Sitagliptin 4.403 MSD Dipeptidyl peptidase inhibitors 4
18th Pegfilgrastim 4,391 Amgen Granulocyte colony stimulating factors
19th Imatinib 4.123 Novartis Protein kinase inhibitor
20th Tenofovir 3,920 Gilead Sciences Nucleosidic Reverse Transcriptase Inhibitors
21st Budesonide 3.878 AstraZeneca Glucocorticoids
22nd Insulin aspart 3.878 Novo Nordisk Insulin analogs
23 Tenofovir + emtricitabine 3,638 Gilead Sciences Nucleosidic Reverse Transcriptase Inhibitors
24 Valsartan 3.391 Novartis AT 1 antagonists
25th Celecoxib 3.177 Pfizer COX-2 inhibitors
26th Oxycodone 3.076 Purdue Pharma Opioid - analgesics
27 Interferon beta-1A 3.024 Biogen Idec Interferons
28 Ezetimibe 3.022 MSD Cholesterol absorption inhibitors
29 Quetiapine 2,588 AstraZeneca Atypical neuroleptics
30th Insulin lispro 2.584 Eli Lilly and Company Insulin analogs
31 Enoxaparin sodium 2.569 Sanofi-Aventis Anticoagulants (heparins)
32 Atorvastatin 2,450 Pfizer Statins
33 Pemetrexed 2,412 Eli Lilly and Company Cytostatics
34 Tadalafil 2,393 Eli Lilly and Company PDE-5 inhibitors

Individual evidence

  1. ↑ Medicines Ranking: Which 10 Medicines Generated the Biggest Sales Worldwide in 2018 - Medscape - Mar 27, 2019
  2. ↑ Top drugs and pharmaceutical companies of 2018 by revenues. Retrieved June 11, 2019 .
  3. ↑ Top drugs by sales in 2017: Who sold the blockbuster drugs? , accessed on June 11, 2019.
  4. ↑ www.gevestor.de/details/die-top-10-der-umsatzstaerksten-medikamente-humira-vor-harvoni-802325.html
  5. ↑ Top 200 Drugs