Mannose-6-phosphate isomerase
| Mannose-6-phosphate isomerase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 422 amino acids | |
| Cofactor | Zn 2+ | |
| Isoforms | 2 | |
| Identifier | ||
| Gene name | MPI | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 5.3.1.8 , isomerase | |
| Response type | Rearrangement | |
| Substrate | Fructose-6-phosphate | |
| Products | Mannose-6-phosphate | |
| Occurrence | ||
| Parent taxon | Eukaryotes , bacteria | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 4351 | 110119 |
| Ensemble | ENSG00000178802 | ENSMUSG00000032306 |
| UniProt | P34949 | Q924M7 |
| Refseq (mRNA) | NM_001289156 | NM_025837 |
| Refseq (protein) | NP_001276085 | NP_080113 |
| Gene locus | Chr 15: 74.89 - 74.9 Mb | Chr 9: 57.54 - 57.55 Mb |
| PubMed search | 4351 |
110119
|
The mannose-6-phosphate isomerase (PMI) is the enzyme that the mutual rearrangement of 6-phosphate fructose in -mannose 6-phosphate and vice versa catalyzed . All living things except the archaea have the enzyme. For eukaryotes , the reaction is important for the biosynthesis of GDP-mannose and the glycans . In bacteria it is part of the mannose metabolism . PMI is localized in the cytosol . In humans, PMI is produced in all types of tissue , especially in the brain , heart and muscles . Mutations in MPI - gene can be rare hereditary Glykosylierungsdefekt lead type 1B (CDG-1B).
Catalyzed reaction
⇔ 
β- D- fructose-6-phosphate and β- D- mannose-6-phosphate merge.
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Fructose, Mannose and Fucose Metabolism - Learning and Teaching Materials
