Marc Feldmann

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Sir Marc Feldmann (born December 2, 1944 in Lemberg ) is a British (according to other information Australian ) immunologist . He is Professor at Oxford University and Director of the Kennedy Institute of Rheumatology. He is known for developing TNF blockers .

Life

Feldmann came from a Jewish family in Poland (near the Soviet border) and came to France with his family immediately after the Second World War. He came to Australia when he was eight. He studied medicine at the University of Melbourne with a bachelor's degree (MBBS) in 1957 and received his doctorate in immunology from the Walter and Eliza Hall Institute of Medical Research in 1972 under Gustav Nossal . In the 1970s he moved to England and worked at Avrion Mitchison in a tumor immunology research group at the Imperial Cancer Research Fund. In 1985 he moved to the Charing Cross Sunley Research Center in London and the Kennedy Institute of Rheumatology, which were attached to Imperial College and, from 2011, Oxford University. He is a fellow at Somerville College .

plant

In the 1980s he published a new hypothesis about the mechanism of autoimmune diseases and the role that cytokines play in them. With Ravinder Maini he studied his theory using rheumatoid arthritis and found an accumulation of the cytokine TNF-α in affected joints. If TNF-alpha was blocked, this led to the reduction of other inflammatory cytokines. Clinical tests with an antibody (infliximab from the biotech company Centocor) that blocked TNF-alpha were successfully carried out in 1992 at Charing Cross Hospital. That was the beginning of the development of the TNF blockers.

Awards

Web links

Individual evidence

  1. ^ The Crafoord Prize 2000 at crafoordprize.se; Retrieved May 25, 2013
  2. ↑ Marc Feldmann and Ravinder Maini at the Lasker Foundation (laskerfoundation.org); Retrieved May 28, 2013
  3. ^ Professor Marc Feldmann (UK) at the European Patent Office (epo.org); Retrieved May 28, 2013
  4. ↑ Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research (PDF, 56 kB) at pauljanssenaward.com; Retrieved May 28, 2013
  5. ^ London Gazette  (Supplement). No. 59446, HMSO, London, June 11, 2010, p. 1 ( PDF , accessed October 10, 2013, English).
  6. ^ Ernst Schering Prize 2010 at the Schering Foundation (scheringstiftung.de); accessed on April 29, 2019
  7. ^ Marc Feldmann at the National Academy of Sciences (nasonline.org); Retrieved May 28, 2013
  8. ↑ Tang Prize 2020
personal data
SURNAME Feldmann, Marc
BRIEF DESCRIPTION British (according to other sources Australian) immunologist
DATE OF BIRTH December 2, 1944
PLACE OF BIRTH Lviv