Ravinder N. Maini

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Ravinder N. Maini, 2013

Sir Ravinder Nath Maini (born November 17, 1937 in Ludhiana , India ) is a British immunologist and rheumatologist of Indian descent. He is best known for his work that led to the development of a new class of drugs called TNF blockers .

Life

Ravinder Nath Maini is the son of Sir Amar Nath Maini (1911–1999), a liberal-conservative British politician of Indian descent in Uganda (then a British colony) and first mayor of Kampala and Saheli Maini, née. Mehra. He spent his childhood in Africa but graduated from school in England.

Maini acquired at Sidney Sussex College of the University of Cambridge a Bachelor of Science degree and then completed a study of medicine . After working at various hospitals in London ( Guy's Hospital , Brompton Hospital, Charing Cross Hospital) between 1962 and 1970, he was consultant at St. Stephen's Hospital, also in London, until 1976 .

In 1979 Maini became head of clinical immunology at Charing Cross and Westminster Medical School (now Imperial College London ) and at the Kennedy Institute of Rheumatology (KIR), and in 1981 he was appointed professor of immunology and rheumatology. In 1990 he became scientific director at KIR; from August 2000 to September 2002 he headed the institute in the course of its merger with Imperial College London. His successor at KIR was Marc Feldmann . From November 2002 until leaving clinical practice in 2007, Maini was Emeritus Honorary Consultant Physician at Charing Cross Hospital and Hammersmith Hospitals Trust in London. Since November 2002 he has been emeritus for rheumatology at Imperial College London.

Maini is married for the second time. The first marriage had four children, one of whom died as a teenager. The second marriage has two children.

Act

As early as the late 1960s, Maini was working at Dudley Dumonde on messenger substances released by lymphocytes .

The work of Maini and his long-term research partner Marc Feldmann dealt with cytokines that are involved in processes of immunity and inflammation , in particular with the molecular basis of rheumatoid arthritis . They used cell cultures obtained from patients (in vitro) as well as test animals from model organisms (in vivo). Together with Fionula M. Brennan , they identified TNF-α ( tumor necrosis factor ) as a central cytokine. Today we know that TNF controls inflammation and tissue destruction in rheumatoid arthritis, psoriatic arthritis , ankylosing spondylitis (ankylosing spondylitis), Crohn's disease and ulcerative colitis , among other things . Maini and Feldmann practiced translational medicine : they developed the hypothesis that a blockade of TNF can inhibit inflammation, checked this hypothesis in laboratory tests, verified it in practice and ultimately also led the studies that led to the approval of the first representative of the new drug group of TNF -Blocker (today this includes several monoclonal antibodies and a fusion protein ) carried out by the responsible authorities in Europe and the USA.

Further work has looked at the blockade of other cytokines, including IL-6 and IL-17 .

Fonts (selection)

  • Immunology of Rheumatic Diseases , 1977
  • Modulation of Autoimmune Disesae (Ed.), 1981
  • Textbook of the Rheumatic Diseases (co-author), 1986
  • T-Cell Activation in Health and Disease (Ed.), 1989
  • Rheumatoid Arthritis (Ed.), 1992
  • Oxford Textbook of Rheumatology (co-author), 1993
  • Rheumatology (co-author), 1993
  • Manual of Biological Markers of Disease (co-author), 1993-1996
  • Oxford Textbook of Medicine (co-author), 2001

Awards (selection)

literature

Web links

Individual evidence

  1. ↑ The Crafoord Prize 2000. crafoordprize.se; Retrieved January 3, 2014
  2. ^ Albert Lasker Clinical Medical Research Award - 2003 Winners at the Lasker Foundation (laskerfoundation.org); Retrieved January 3, 2014
  3. ^ New year's honors 2003. The Guardian, December 31, 2002
  4. ^ Fellows of the Royal Society (royalsociety.org); Retrieved January 3, 2014
  5. ↑ Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research at pauljanssenaward.com; Retrieved January 3, 2014
  6. ^ Ernst Schering Prize 2010 at the Schering Foundation (scheringstiftung.de); Retrieved January 3, 2014
  7. ^ Ravinder Maini at the National Academy of Sciences (nasonline.org); Retrieved January 3, 2014
personal data
SURNAME Maini, Ravinder N.
ALTERNATIVE NAMES Maini, Ravinder; Maini, Ravinder Nath (full name)
BRIEF DESCRIPTION British immunologist and rheumatologist of Indian descent
DATE OF BIRTH November 17, 1937
PLACE OF BIRTH Ludhiana , India