Michael E. Greenberg
Michael Eldon Greenberg (* 1954 in Florida ) is an American neuroscientist at Harvard Medical School . He is known for the discovery of signal transduction , which underlies the activity-dependent gene transcription of neurons .
Life
Greenberg grew up as the youngest of four children in Brooklyn , New York City . In 1976 he completed his studies in chemistry at the Wesleyan University from 1982 he acquired at Gerald Edelman at Rockefeller University a Ph.D. in biochemistry . As a postdoctoral fellow he worked with the biologist Edward Ziff at New York University .
In 1986 Greenberg received a position as an assistant professor at Harvard Medical School . In 1994 he moved to the Department of Neurology at Children's Hospital Boston before returning to Harvard Medical School in 2008 . Here he holds the chair of neurobiology (as of 2015) .
Act
Greenberg deals with the relationship between genetics and environmental influences on human brain development and the development of disorders such as autism or intellectual disability . In 1984 he discovered that growth factors on the cell surface on the cell nucleus effect the transcription of the C-Fos . In addition, Greenberg and co-workers were able to show that neuronal activity triggers this process and activates hundreds of other genes. Greenberg turned neural mechanisms of this process is, including that of the voltage-dependent calcium channel L-type , the gene expression in the development of synapses strikes - and thus on the one hand as important for processes learning or memory has, on the other hand for the development of disorders stimulating from an imbalance of and inhibitory synapses result. Using cell cultures from mouse neurons, Greenberg was able to prove that sensory stimuli lead to the activation of enhancer genes and the formation of e-RNA (enhancer RNA), which in turn seem to play a role in the cell's response to the sensory stimulus. In more recent work, he reported that a disruption of the MeCP-2 gene has severe effects on the development of other neuronal genes, which in turn leads to neurological disorders such as Rett syndrome . Further work deals with the role of the growth factor BDNF in Rett syndrome and other disorders.
Awards (selection)
- 2003 member of the American Academy of Arts and Sciences
- 2006 Harvey Lecture : Signaling Networks That Control Synapse Development and Cognitive Function.
- 2008 Perl-UNC Neuroscience Prize
- 2008 member of the National Academy of Sciences
- 2010 Fellow of the American Association for the Advancement of Science
- 2015 Gruber Prize for Neuroscience
- 2019 Ralph W. Gerard Prize
Web links
- Michael Greenberg, Ph.D. at the Department of Neurobiology at Harvard Medical School (hms.harvard.edu)
- Michael E. Greenberg, Ph.D. at the Rett Syndrome Research Trust
Individual evidence
- ↑ Book of Members 1780 – present, Chapter G. (PDF; 931 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved May 1, 2019 .
- ↑ Harvey Society (Ed.): The Harvey Lectures . John Wiley & Sons , 2010, ISBN 978-0-470-59303-5 , pp. 172 ( limited preview in Google Book search).
- ↑ Previous Recipients - UNC Neuroscience Center - UNC School of Medicine. In: med.unc.edu. October 23, 2014, accessed June 7, 2015 .
- ↑ Michael Greenberg. In: nasonline.org. Retrieved June 7, 2015 .
- ↑ 2015 Gruber Neuroscience Prize - The Gruber Foundation. In: gruber.yale.edu. Retrieved June 7, 2015 .
| personal data | |
|---|---|
| SURNAME | Greenberg, Michael E. |
| ALTERNATIVE NAMES | Greenberg, Michael Eldon; Greenberg, Michael |
| BRIEF DESCRIPTION | American neuroscientist |
| DATE OF BIRTH | 1954 |
| PLACE OF BIRTH | Florida |