Michel Cuénod

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Michel Cuénod (born March 23, 1933 in Belfort ) is a Swiss neurobiologist and professor at the University of Zurich .

life and career

Michel Cuénot is the son of an engineer and studied medicine in Lausanne , where he received his doctorate in 1957. med. received his doctorate. He then worked at the Physiological Institute of the University of Lausanne, from 1960 at the Bel Air Psychiatric Clinic in Geneva and in 1961 at the National Institutes of Health in Bethesda (Maryland) . From 1963 he was at Columbia University and from 1965 at the Institute for Brain Research at the University of Zurich, where he became a private lecturer in 1971, associate professor in 1973 and full professor of neurobiology in 1984 and director of the institute. In 1998 he retired and was then visiting professor in Lausanne (CHUV, Department of Psychiatry).

He developed a split brain model of the pigeon's visual system, worked on rapid axonal transport and, with colleagues, developed the method of transmitter-specific retrograde labeling, in which neural circuits are selectively marked according to the transmitter used for signal transmission . When investigating the optical nervous system, he found that homocysteate (a sulfur-containing glutamic acid analog) acts as a transmitter for nerve cell excitation at the NMDA receptors of the glial cells (i.e., is a glial transmitter). He also made contributions to the understanding of the role of nitric oxide in signal transmission to synapses. Together with Kim Quang Do , he advocates the theory that a disturbed redox reaction equilibrium due to a genetically determined impaired glutathione synthesis is one of the causes of schizophrenia .

He also published on the central control of the vasoreceptors, influence of visual stimuli on the limbic system and metabolism of histones .

In 1988 he and others founded the European Journal of Neuroscience , which he published from 1993 to 1997. 1986 to 1988 he was President of the European Neuroscience Association. From 1993 to 2000 he was Secretary General of the Human Frontier Science Program, in which he promoted international collaboration in molecular biology and neurosciences.

In 1973 he received the Robert Bing Prize for Neurology from the Swiss Academy of Medicine and in 1979 the Marcel Benoist Prize . He also received the Prix César Roux from the Faculty of Medicine in Lausanne. He is an honorary doctorate from the University of Geneva (1994). Cuénod is a member of the Swiss Academy for Medical Sciences . In 2007 he became an honorary member of the Swiss Society for Neuroscience. Since 1989 he has been a member of the Academia Europaea .

He was married twice, first to Catherine Rossier, and second to the neurobiologist and professor in Lausanne Kim Quang Do.

Cuénod is a citizen of Vevey and Corsier-sur-Vevey .

Fonts

  • Editor with W. Maxwell Cowan : The use of axonal transport for studies of neuronal connectivity, Elsevier 1975
  • Editor: Development and chemical specificity of neurons: proceedings of the Schatzalp Symposium, September 1978, Elsevier 1979

Web links

Individual evidence

  1. ^ Cuénod, Split Brain Studies. Functional interaction between bilateral central nervous structures, in GH Bourne, The structure and function of the neurons tissue, Volume 5, Academic Press 1972, pp. 455-506
  2. ↑ J. Boesch, Cuenod, P. Marko, M. Perisic, C. Sandri, J. Schonbach: Contributions of axoplasmic transport to synaptic structure and function, Int. J. Neuroscience, Vol. 4, 1972, pp. 77-87
  3. ↑ Cuenod, J. Schonbach, Synaptic proteins and axonal flow in the pigeon visual pathway, J. Neurochemistry, Volume 18, 1971, pp. 809-816
  4. ^ P. Streit, E. Knecht, M. Cuenot, Transmitter-specific retrograde labeling in the striato-nigral and raphe-nigral pathways, Science, Volume 205, 1979, pp. 306-308, PMID 451602
  5. ↑ P. Grandes, KQD Kq, P. Morino, M. Cuénod, P. Streit: Homocysteate, an Excitatory Transmitter Candidate Localized in Glia, The European Journal of Neuroscience, Volume 3, 1991, pp. 1370-1373
  6. ↑ KQ Do, AH Trabesinger, M. Kirsten-Kruger, CJLaurer, U. Dydak, D. Hell, F. Holsboer, P. Boesiger, M. Cuenod: Schizophrenia: glutathione deficit in cerebro spinal fluid and prefrontal cortex in vivo. European Journal of Neuroscience, Volume 12, 2000, pp. 3721-3728
  7. ^ V Castagne, M. Rougemont, M. Cuenod, KQ Do: Low brain glutathione levels and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia. Neurobiology of Disease, Vol. 15, 2004, pp. 93-105
  8. ↑ P. Steullet, HC Neijt, M. Cuenod, KQ Do: Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia, Neuroscience, Volume 137, 2006, pp. 807-819
  9. ^ RS Piha, M. Cuénod, H. Waelsch :. Metabolism of histones of brain and liver. J Biol Chem., Vol. 241, 1966, pp. 2397-2404
  10. ^ Website of Kim Q. Do at the University of Lausanne
personal data
SURNAME Cuénod, Michel
BRIEF DESCRIPTION Swiss neurobiologist and professor at the University of Zurich
DATE OF BIRTH March 23, 1933
PLACE OF BIRTH Belfort