N -acetylsulfanilyl chloride

Structural formula
General
Surname	N-acetylsulfanilyl chloride
other names	N -acetylsulfanilyl chloride; 4- (acetylamino) benzenesulfonic acid chloride; 4- (acetylamino) benzenesulfonyl chloride; 4-acetamidobenzenesulfonic acid chloride; N -acetylsulfanilic acid chloride;
Molecular formula	C 8 H 8 ClNO 3 S
Brief description	white solid with an acetic acid odor
External identifiers / databases
EC number	204-485-1
ECHA InfoCard	100.004.078
PubChem	8481
ChemSpider	8168
DrugBank	DB12337
Wikidata	Q26841247
properties
Molar mass	233.67 g mol −1
Physical state	firmly
solubility	decomposes in water; soluble in benzene, chloroform and ether;
safety instructions
H and P phrases	H: 314-335
	P: 261-280-305 + 351 + 338-310
Toxicological data	> 3200 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

N -acetylsulfanilyl chloride is a chemical compound from the group of carboxamides and sulfonyl halides .

Extraction and presentation

N- acetylsulfanilyl chloride can be obtained by reacting acetanilide with chlorosulfonic acid at elevated temperatures.

properties

N -acetylsulfanilyl chloride is a flammable, hardly ignitable, white solid with an acetic acid- like odor that decomposes in water to form hydrochloric and acetic acid. It also decomposes when heated above 146 ° C.

use

N -acetylsulfanilyl chloride is used as an intermediate in the manufacture of other chemical compounds (such as sulfadimidine , dimethylsulfanilamide and sulfanilamide ).

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Entry on N-acetylsulfanilyl chloride in the GESTIS substance database of the IFA , accessed on July 1, 2017(JavaScript required) .
↑ Data sheet 4-Acetamidobenzenesulfonyl chloride, 98 +% from AlfaAesar, accessed on July 1, 2017 ( PDF )(JavaScript required) .
↑ Entry on 4- (acetylamino) benzenesulfonyl chloride in the Hazardous Substances Data Bank , accessed on July 1, 2017.
↑ Data sheet N-Acetylsulfanilyl chloride, 98% from Sigma-Aldrich , accessed on July 1, 2017 ( PDF ).
^ Profiles of Drug Substances, Excipients and Related Methodology . Academic Press, 1978, ISBN 978-0-08-086102-9 , pp. 413 ( limited preview in Google Book search).

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g Entry on N-acetylsulfanilyl chloride in the GESTIS substance database of the IFA , accessed on July 1, 2017(JavaScript required) .

[Alfa-2] Data sheet 4-Acetamidobenzenesulfonyl chloride, 98 +% from AlfaAesar, accessed on July 1, 2017 ( PDF )(JavaScript required) .

[HSDB-3] Entry on 4- (acetylamino) benzenesulfonyl chloride in the Hazardous Substances Data Bank , accessed on July 1, 2017.

[Sigma-4] Data sheet N-Acetylsulfanilyl chloride, 98% from Sigma-Aldrich , accessed on July 1, 2017 ( PDF ).

[5] Profiles of Drug Substances, Excipients and Related Methodology . Academic Press, 1978, ISBN 978-0-08-086102-9 , pp. 413 ( limited preview in Google Book search).