Owen N. Witte

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Owen Neil Witte (born March 17, 1949 in Brooklyn , New York ) is an American molecular biologist and cancer researcher at the University of California, Los Angeles .

Live and act

Witte earned a bachelor's degree from Cornell University in 1971 and an MD from Stanford University in 1976 with a medical degree. As a postdoctoral fellow , he worked with Nobel Prize winner David Baltimore at the Massachusetts Institute of Technology .

Since 1980 Witte has been Professor of Microbiology, Immunology and Molecular Genetics at the University of California, Los Angeles . from 1986 to 2016 he also conducted research for the Howard Hughes Medical Institute (HHMI).

Witte was able to make important contributions to the understanding of leukemia and cancer stem cells of epithelial tumors (including prostate cancer ). He discovered the tyrosine kinase activity of the ABL gene product and was able to show that the BCR -ABL fusion protein can act as an oncogene . His work on the relationships between regulation of cell growth and cell differentiation was fundamental to the development of new cancer drugs (such as imatinib and ibrutinib ). Witte's further work dealt with various tyrosine kinases (including BTK ), with cell surface antigens of cancer cells such as PSCA (prostate stem cell antigen) , with neuroendocrine properties of aggressive tumor cells. Among other things, he uses positron emission tomography and other imaging techniques to show malignant cell populations and certain aspects of tumor metabolism and the immune response .

Witte is the author or co-author of more than 400 scientific publications . According to the Scopus database , he has an h-index of 102 (as of October 2019). Charles L. Sawyers is one of his students.

In 1996 Witte was elected a member of the American Academy of Arts and Sciences , and in 1997 a member of the National Academy of Sciences . He has also been a member of the Institute of Medicine (now the National Academy of Medicine ) since 2003 and a Fellow of the American Association for Cancer Research since 2014 . In 1993 he received the Dameshek Prize of the American Society of Hematology , and in 2000 the Warren Alpert Foundation Prize .

Web links

Individual evidence

  1. ↑ Owen N. Witte. In: hhmi.org. Howard Hughes Medical Institute , accessed October 20, 2019 .
  2. ^ Witte, Owen N. In: scopus.com. Scopus , accessed on 20 October 2019 (English).
  3. ↑ Book of Members 1780 – present, Chapter W. (PDF; 852 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved October 20, 2019 .
  4. ↑ Owen N. Witte. In: nasonline.org. National Academy of Sciences , accessed October 20, 2019 .
  5. ↑ Owen N. Witte, MD. In: aacr.org. American Association for Cancer Research , accessed October 20, 2019 .
  6. ^ William Dameshek Prize Recipients. In: hematology.org. American Society of Hematology , accessed October 20, 2019 .
  7. ↑ Owen Witte. In: warrenalpert.org. Warren Alpert Foundation Prize , accessed October 20, 2019 .
personal data
SURNAME Witte, Owen N.
ALTERNATIVE NAMES Witte, Owen; Witte, Owen Neil
BRIEF DESCRIPTION American molecular biologist and cancer researcher
DATE OF BIRTH March 17, 1949
PLACE OF BIRTH Brooklyn , New York