Paul R. Schimmel

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Paul R. Schimmel, 2010

Paul Reinhard Schimmel (born August 4, 1940 in Hartford , Connecticut ) is an American biochemist and biophysicist .

Schimmel obtained a bachelor's degree from Ohio Wesleyan University in 1962 and initially studied medicine at Tufts University , but after a year he switched to the Massachusetts Institute of Technology (MIT), where he did a PhD in 1966 with Gordon Hammes with a thermodynamic thesis on enzyme kinetics . D. acquired. As a postdoctoral fellow he worked with the later Nobel Prize winner Paul Flory at Stanford University . After a year, Schimmel returned to MIT, where he became a professor of biochemistry and biophysicsbefore moving to the Scripps Research Institute in 1997 . Here he is (as of 2018) Professor in the Department of Cell and Molecular Biology .

Through his analysis of the aminoacyl-tRNA synthetases, Schimmel was able to contribute significantly to the understanding of the protein-RNA interactions that form the basis of the universal genetic code . He showed how features in small RNA structures are interpreted as specific amino acids , sometimes referred to as the "second genetic code". He found that the RNA structure plays an essential role in improving the accuracy of the genetic code through an error correction mechanism. Nature magazine identified his development of the Expressed Sequence Tags as one of the four key developments on which the human genome project is based.

In 1970 he received a research grant from the Alfred P. Sloan Foundation ( Sloan Research Fellowship ). Schimmel received the Pfizer Award in Enzyme Chemistry in 1978 . In 1987 he was elected to the American Academy of Arts and Sciences , in 1990 to the National Academy of Sciences and in 1999 to the American Philosophical Society .

Web links

Individual evidence

  1. ^ Nicole Kresge, Robert D. Simoni, Robert L. Hill: Editing Mischarged Amino Acids: the Work of Paul R. Schimmel. In: Journal of Biological Chemistry , April 9, 2010; 285 (15): e4-e6. DOI: 10.1074 / jbc.O110.000227
  2. ^ Pfizer Award in Enzyme Chemistry (PDF, 48 kB); accessed on February 10, 2018.
  3. ↑ Book of Members 1780 – present, Chapter S. (PDF; 1.4 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved February 10, 2018 .
  4. ↑ Paul Schimmel. In: nasonline.org. Retrieved February 10, 2018 .
  5. ↑ Dr. Paul Schimmel. In: search.amphilsoc.org. Retrieved February 10, 2018 .
personal data
SURNAME Schimmel, Paul R.
ALTERNATIVE NAMES Schimmel, Paul Reinhard
BRIEF DESCRIPTION American biochemist and biophysicist
DATE OF BIRTH 4th August 1940
PLACE OF BIRTH Hartford , Connecticut