Pivmecillinam
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Non-proprietary name | Pivmecillinam | |||||||||||||||||||||
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Molecular formula | C 21 H 33 N 3 O 5 S | |||||||||||||||||||||
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pK s value |
8.9 |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Pivmecillinam is a semi-synthetic, antibiotic active substance from the group of β-lactam antibiotics , which was patented by LEO Pharma in 1971 . The compound is used almost exclusively as a hydrochloride .
application
Pivmecillinam has been used for decades, especially in the Scandinavian countries, to treat uncomplicated urinary tract infections . Since 2010, due to the favorable resistance situation, it has also been recommended in the German-language S3 guideline for the treatment of urinary tract infections as the first choice for the treatment of uncomplicated cystitis . The drug has been available on the German market since 2016 and approved for men and women aged 18 and over. It is particularly effective against gram-negative pathogens.
Mode of action
The bacteriostatic effect of Pivmecillinam based (somewhat different from other β-lactam antibiotics) on the blocking of penicillin - binding protein 2 (PBP2). This prevents the formation of a new cell wall in the case of bacteria in the dividing phase.
Trade names
Selexid (A), X-Systo (D), Pivmelam (D)
Web links
- Pivmecillinam - a new penicillin derivative for oral use , ZCT issue 2, 1985
Individual evidence
- ↑ a b c d e f Entry on Pivmecillinam. In: Römpp Online . Georg Thieme Verlag, accessed on July 24, 2019.
- ↑ a b c Entry on pivotmecillinam in the ChemIDplus database of the United States National Library of Medicine (NLM) .
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ a b Drugs in Japan Vol. 6 , p. 632, 1982.
- ^ Wagenlehner, Florian ME; Hoyme, Udo; Kaase, Martin; Five piece, Reinhard; Naber, Kurt G .; Schmiemann, Guido: Clinical Guideline Uncomplicated Urinary Tract Infections (2011). In: Dtsch Arztebl Int 2011; 108 (24): 415-423. Retrieved June 20, 2011 .
- ↑ technical information X Systo. Retrieved June 30, 2017 .
- ↑ New, HC: Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use . In: Pharmacotherapy . 1985 Jan-Feb; 5 (1): 1-10. PMID 3885172 .