Procarbazine
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Non-proprietary name | Procarbazine | ||||||||||||||||||
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Molecular formula | C 12 H 19 N 3 O | ||||||||||||||||||
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Molar mass | 221,30 g · mol -1 | ||||||||||||||||||
Physical state |
firmly |
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Melting point |
223–226 ° C (monohydrochloride) |
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pK s value |
6.8 ( monohydrochloride ) |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Procarbazine (trade name: Natulan ® ) is a chemotherapeutic agent that belongs to the group of alkylating agents . It is a prodrug that is converted to azoprocarbazine . The metabolism takes place hepatically and in the erythrocytes .
The drug is used , among other things, to treat Hodgkin's disease , non-Hodgkin's lymphoma , cerebral neoplasms and a certain form of lung cancer , small cell lung cancer .
Common side effects are the development of a deficiency in white blood cells (leukocytes) and blood platelets (thrombocytes), so-called leukopenia or thrombocytopenia . In addition, it can lead to nausea, vomiting , sterility and sensitivity disorders.
Procarbazine has also been causally linked to pleural effusion .
literature
- von Planta (ed.): Internal medicine . 4th edition. Chapman & Hall; 1996 ISBN 3-432-30371-8 .
- Anticancéreux: utilization pratique , 5ième édition, CNHIM, août-septembre 2004, XXV, 4–5.
Individual evidence
- ↑ a b c Entry on procarbazine. In: Römpp Online . Georg Thieme Verlag, accessed on June 1, 2014.
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Berthold Jany, Tobias Welte: Pleural effusion in adults - causes, diagnosis and therapy. In: Deutsches Ärzteblatt. Volume 116, No. 21, (May) 2019, pp. 377-385, here: p. 380.