Procarbazine

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Structural formula
Structural formula of procarbazine
General
Non-proprietary name Procarbazine
other names
  • N -isopropyl-4- (2-methylhydrazinomethyl) benzamide ( IUPAC )
  • Procarbazinum ( Latin )
Molecular formula C 12 H 19 N 3 O
External identifiers / databases
CAS number 671-16-9
EC number 211-582-2
ECHA InfoCard 100.010.531
PubChem 4915
DrugBank DB01168
Wikidata Q418656
Drug information
ATC code

L01 XB01

Drug class

Cytostatic

properties
Molar mass 221,30 g · mol -1
Physical state

firmly

Melting point

223–226 ° C (monohydrochloride)

pK s value

6.8 ( monohydrochloride )

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
Toxicological data

614 mg kg −1 ( LD 50 ,  mouse ,  ip )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Procarbazine (trade name: Natulan ® ) is a chemotherapeutic agent that belongs to the group of alkylating agents . It is a prodrug that is converted to azoprocarbazine . The metabolism takes place hepatically and in the erythrocytes .

The drug is used , among other things, to treat Hodgkin's disease , non-Hodgkin's lymphoma , cerebral neoplasms and a certain form of lung cancer , small cell lung cancer .

Common side effects are the development of a deficiency in white blood cells (leukocytes) and blood platelets (thrombocytes), so-called leukopenia or thrombocytopenia . In addition, it can lead to nausea, vomiting , sterility and sensitivity disorders.

Procarbazine has also been causally linked to pleural effusion .

literature

  • von Planta (ed.): Internal medicine . 4th edition. Chapman & Hall; 1996 ISBN 3-432-30371-8 .
  • Anticancéreux: utilization pratique , 5ième édition, CNHIM, août-septembre 2004, XXV, 4–5.

Individual evidence

  1. ↑ a b c Entry on procarbazine. In: Römpp Online . Georg Thieme Verlag, accessed on June 1, 2014.
  2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. ↑ Berthold Jany, Tobias Welte: Pleural effusion in adults - causes, diagnosis and therapy. In: Deutsches Ärzteblatt. Volume 116, No. 21, (May) 2019, pp. 377-385, here: p. 380.