Profluralin

Structural formula
General
Surname	Profluralin
other names	N - (Cyclopropylmethyl) -α, α, α-trifluoro-2,6-dinitro- N -propyl- p -toluidine; Tolban;
Molecular formula	C 14 H 16 F 3 N 3 O 4
External identifiers / databases
EC number	247-656-6
ECHA InfoCard	100.043.309
PubChem	33500
ChemSpider	30913
Wikidata	Q15632821
properties
Molar mass	347.29 g mol −1
Physical state	firmly
density	1.38 g cm −3 (20 ° C)
Melting point	32.1-32.5 ° C
solubility	practically insoluble in water (1 mg l −1 at 20 ° C)
safety instructions
H and P phrases	H: 319-410
	P: 273-305 + 351 + 338-501
Toxicological data	1810 mg kg −1 ( LD 50 , rat , oral ) ; 13800 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Profluralin is a chemical compound from the group of dinitrotoluidines and dinitroanilines .

Extraction and presentation

Profluralin can be obtained by a multi-stage reaction of cyclopropanecarbonyl chloride with propylamine , lithium aluminum hydride and 3,5-dinitro-4-chlorobenzotrifluoride (DTFB).

use

Profluralin was used as a pre-emergence herbicide . The effect is based on the inhibition of the formation of microtubules .

Admission

The active ingredient profluralin is not on the list of active ingredients of plant protection products permitted in the EU. In Germany, Austria and Switzerland, no plant protection product containing profluralin is permitted.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f Entry on Profluralin in the GESTIS substance database of the IFA , accessed on February 9, 2017(JavaScript required) .
^ SD Gangolli, Royal Society of Chemistry (Great Britain): The Dictionary of Substances and Their Effects (DOSE): Volume 06 OS . Royal Society of Chemistry, 1999, ISBN 0-85404-833-2 , pp. 506 ( limited preview in Google Book search).
↑ Entry on Profluralin in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
↑ ^a ^b Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 879 ( limited preview in Google Book search).
^ Directorate-General for Health and Food Safety of the European Commission: EU pesticide database ; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved February 19, 2016.

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f Entry on Profluralin in the GESTIS substance database of the IFA , accessed on February 9, 2017(JavaScript required) .

[dose-2] SD Gangolli, Royal Society of Chemistry (Great Britain): The Dictionary of Substances and Their Effects (DOSE): Volume 06 OS . Royal Society of Chemistry, 1999, ISBN 0-85404-833-2 , pp. 506 ( limited preview in Google Book search).

[CLP_100.043.309-3] Entry on Profluralin in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on August 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .

[unger-4] Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 879 ( limited preview in Google Book search).

[PSM-5] Directorate-General for Health and Food Safety of the European Commission: EU pesticide database ; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved February 19, 2016.