Pyriofenone

Structural formula
General
Surname	Pyriofenone
other names	(5-chloro-2-methoxy-4-methyl-3-pyridinyl) (2,3,4-trimethoxy-6-methylphenyl) methanone
Molecular formula	C 18 H 20 ClNO 5
Brief description	white solid
External identifiers / databases
EC number	692-456-8
ECHA InfoCard	100.220.471
PubChem	23082663
ChemSpider	16110824
Wikidata	Q19298811
properties
Molar mass	365.8 g mol −1
Physical state	firmly
density	1.36 g cm −3
Melting point	93-95 ° C
boiling point	> 100 ° C (decomposition)
Vapor pressure	1.9 × 10 −6 hPa (25 ° C)
solubility	practically insoluble in water (1.56 mg l −1 at 20 ° C); readily soluble in xylene, 1,2-dichloroethane, acetone and ethyl acetate;
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
Toxicological data	> 2000 mg kg −1 ( LD 50 , rat , oral ) ; > 2000 mg kg −1 ( LD 50 , rat , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Pyriofenone is a chemical compound from the group of benzophenone derivatives .

properties

Pyriofenone is a white solid that is practically insoluble in water.

use

Pyriofenone is used as a fungicide . The compound was discovered and developed by ISK Biosciences . It should be used in grain, wine and other arable and vegetable crops and is particularly effective against powdery mildew (e.g. Erysiphe , Leveillula , Podosphaera , Sphaeroteca, etc.).

Admission

It received preliminary approval in January 2010 and is structurally very similar to the compound metrafenone . The connection has been approved in the EU since February 1, 2014.

No pesticide products containing this active ingredient are approved in Switzerland, but in Germany and Austria.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k EFSA: Conclusion on the peer review of the pesticide risk assessment of the active substance pyriofenone. In: EFSA Journal. 11, 2013, p. 3147, doi : 10.2903 / j.efsa.2013.3147 .

↑ EPA Factsheet: Pyriofenone , accessed December 25, 2014.

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

↑ ISK Biosciences: Pyriofenone - A New Fungicide to Control Powdery Mildew in Grains and Wine

↑ Ulrich Schirmer, Peter Jeschke, Matthias Witschel: Modern Crop Protection Compounds: Herbicides . John Wiley & Sons, 2012, ISBN 978-3-527-32965-6 , pp. 893 ( limited preview in Google Book search).

↑ EU: Implementing Regulation (EU) No. 833/2013 of the Commission of 30 August 2013 for the approval of the active substance pyriofenone according to Regulation (EC) No. 1107/2009 of the European Parliament and of the Council on the placing of plant protection products on the market and amending the Annex of Implementing Regulation (EU) No. 540/2011 (PDF) , accessed on December 25, 2014.

↑ Directorate-General for Health and Food Safety of the European Commission: Entry on pyriofenones in the EU pesticide database ; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on December 6, 2019.

[efsa-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k EFSA: Conclusion on the peer review of the pesticide risk assessment of the active substance pyriofenone. In: EFSA Journal. 11, 2013, p. 3147, doi : 10.2903 / j.efsa.2013.3147 .

[EPA-2] EPA Factsheet: Pyriofenone , accessed December 25, 2014.

[NV-3] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[ISK_Biosciences-4] ISK Biosciences: Pyriofenone - A New Fungicide to Control Powdery Mildew in Grains and Wine

[Ulrich_Schirmer,_Peter_Jeschke,_Matthias_Witschel-5] Ulrich Schirmer, Peter Jeschke, Matthias Witschel: Modern Crop Protection Compounds: Herbicides . John Wiley & Sons, 2012, ISBN 978-3-527-32965-6 , pp. 893 ( limited preview in Google Book search).

[EU-6] EU: Implementing Regulation (EU) No. 833/2013 of the Commission of 30 August 2013 for the approval of the active substance pyriofenone according to Regulation (EC) No. 1107/2009 of the European Parliament and of the Council on the placing of plant protection products on the market and amending the Annex of Implementing Regulation (EU) No. 540/2011 (PDF) , accessed on December 25, 2014.