Salvage Pathway

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Nucleotide salvage ( German Bergungsweg ) is generally the term used for metabolic pathways , the synthesis of a biomolecule accomplish from its breakdown products - a form of recycling . A salvage pathway is a form of biochemical recovery process . In particular, the salvage pathway means that for purine nucleotides .

Purine nucleotide salvage

Nucleotide salvage
recovery process
AMP salvage
GMP salvage
IMP salvage
XMP salvage
Gene Ontology

The salvage pathway is used in the cytoplasm for the formation of mononucleotides from the free purine bases adenine , guanine and hypoxanthine . In addition to the breakdown to uric acid , it represents the main metabolic pathway for free purines with 90% . Compared to the de novo biosynthesis of purine mononucleotides, it is significantly more energy-efficient.


A ribose phosphate is transferred to phosphoribosyl pyrophosphate (PRPP) on a free purine base with elimination of pyrophosphate . This creates the corresponding nucleotide.

The catalyzing enzymes are allosterically activated by PRPP and inhibited by their products.

Purine base + PRPP = nucleotide by means of enzyme
Adenine Adenosine monophosphate (AMP) Adenine phosphoribosyl transferase (APRT)
Guanine Guanosine monophosphate (GMP) Hypoxanthine Guanine Phosphoribosyltransferase (HGPRT)
Hypoxanthine Inosine monophosphate (IMP) Hypoxanthine Guanine Phosphoribosyltransferase (HGPRT)


A defect in the salvage pathway can lead to hyperuricemia .

A genetic defect in HGPRT leads to Lesch-Nyhan syndrome .

Web links

Wikibooks: Purine Metabolism  - Learning and Teaching Materials

Individual evidence

  1. Florian Horn et al., Human Biochemistry. 3. Edition. Thieme Verlag, Stuttgart 2005, ISBN 3-13-130883-4 .