Nucleotide salvage ( German Bergungsweg ) is generally the term used for metabolic pathways , the synthesis of a biomolecule accomplish from its breakdown products - a form of recycling . A salvage pathway is a form of biochemical recovery process . In particular, the salvage pathway means that for purine nucleotides .
Purine nucleotide salvage
The salvage pathway is used in the cytoplasm for the formation of mononucleotides from the free purine bases adenine , guanine and hypoxanthine . In addition to the breakdown to uric acid , it represents the main metabolic pathway for free purines with 90% . Compared to the de novo biosynthesis of purine mononucleotides, it is significantly more energy-efficient.
The catalyzing enzymes are allosterically activated by PRPP and inhibited by their products.
|Purine base||+ PRPP = nucleotide||by means of enzyme|
|Adenine||Adenosine monophosphate (AMP)||Adenine phosphoribosyl transferase (APRT)|
|Guanine||Guanosine monophosphate (GMP)||Hypoxanthine Guanine Phosphoribosyltransferase (HGPRT)|
|Hypoxanthine||Inosine monophosphate (IMP)||Hypoxanthine Guanine Phosphoribosyltransferase (HGPRT)|
A defect in the salvage pathway can lead to hyperuricemia .
A genetic defect in HGPRT leads to Lesch-Nyhan syndrome .
- Florian Horn et al., Human Biochemistry. 3. Edition. Thieme Verlag, Stuttgart 2005, ISBN 3-13-130883-4 .