Susan Band Horwitz
Susan Band Horwitz (born 1937 in Boston ) is an American biochemist and molecular pharmacologist at the Albert Einstein College of Medicine in New York City . She is best known for her contributions to research into the chemotherapy drug paclitaxel (Taxol).
Live and act
Horwitz first studied biology at Bryn Mawr College ( Bachelor 1958) and in 1963 earned a Ph.D. from Nathan O. Kaplan at Brandeis University. in biochemistry . As a postdoctoral fellow , she worked in the pharmacology departments at Tufts University , Emory University, and Albert Einstein College of Medicine . She has been a member of the teaching staff here since 1970 and is now (as of 2016) Rose C. Falkenstein Professor of Cancer Research in the Department of Molecular Pharmacology.
Horwitz is interested in natural substances as starting points for new drugs with an effectiveness against cancer . For several decades she researched active substances that serve as lead substances for important chemotherapeutic agents. So she was able to contribute significantly to the elucidation of the mechanisms of action of camptothecin , epipodophyllotoxins and bleomycin . The most important achievement of Horwitz is the elucidation of the mechanism of action of paclitaxel (taxol), a taxane that occurs in the Pacific yew ( Taxus brevifolia ). Further work deals with the acquired resistance of tumor cells to certain drugs, including taxol (see Multiple Drug Resistance ).
Horwitz has been married since 1960 and she is the mother of twins.
Awards (selection)
- 1994 member of the American Academy of Arts and Sciences
- 2002 President of the American Association for Cancer Research
- 2004 Warren Alpert Foundation Prize
- 2005 member of the National Academy of Sciences
- 2006 member of the Institute of Medicine
- 2006 Bristol-Myers Squibb Award
- 2011 AACR Award for Lifetime Achievement in Cancer Research
- 2013 member of the American Philosophical Society
- 2019 Canada Gairdner International Award
- 2020 Szent-Györgyi Prize
literature
- TH Davis: Profile of Susan Band Horwitz. In: Proceedings of the National Academy of Sciences . 103, 2006, p. 10163, doi: 10.1073 / pnas.0604639103 .
- Susan Band Horwitz, I. David Goldman: A Conversation with Susan Band Horwitz. In: Annual Review of Pharmacology and Toxicology . 55, 2015, p. 1, doi: 10.1146 / annurev-pharmtox-010814-124519 .
Web links
- Susan B. Horwitz, Ph.D. at the Albert Einstein College of Medicine (einstein.yu.edu)
- Susan Band Horwitz, PhD at the American Association for Cancer Research (aacr.org)
Individual evidence
- ^ Book of Members 1780 – present. (PDF, 1.4 MB) from the American Academy of Arts and Sciences (amacad.org); Retrieved December 3, 2016.
- ^ Presidents of the AACR. In: aacr.org. December 3, 2016, accessed December 3, 2016 .
- ^ Susan Band Horwitz. In: warrenalpert.org. Retrieved December 3, 2016 .
- ↑ Susan Horwitz. In: nasonline.org. Retrieved December 3, 2016 .
- ↑ GRANTS AND AWARDS PROGRAM - FACT SHEET (PDF, 506 kB) at Bristol-Myers Squibb (bms.com); Retrieved December 3, 2016.
- ^ AACR Award for Lifetime Achievement in Cancer Research. In: aacr.org. April 17, 2016, accessed December 3, 2016 .
- ^ American Philosophical Society - Member History. In: amphilsoc.org. Retrieved December 3, 2016 .
- ↑ Canada Gairdner International Award 2019
| personal data | |
|---|---|
| SURNAME | Horwitz, Susan Band |
| ALTERNATIVE NAMES | Horwitz, Susan B. |
| BRIEF DESCRIPTION | American biochemist and molecular pharmacologist |
| DATE OF BIRTH | 1937 |
| PLACE OF BIRTH | Boston |