Temephos

Structural formula
General
Surname	Temephos
other names	O , O '- (thiodi- p -phenylene) to ( O , O ' - dimethyl thiophosphate); Temefos; Abate;
Molecular formula	C 16 H 20 O 6 P 2 S 3
Brief description	colorless (white) solid
External identifiers / databases
EC number	222-191-1
ECHA InfoCard	100.020.175
PubChem	5392
DrugBank	DB12231
Wikidata	Q417958
properties
Molar mass	466.48 g mol −1
Physical state	firmly
density	1.32 g cm −3
Melting point	30-30.5 ° C
boiling point	Decomposes before boiling point is reached
solubility	practically insoluble in water
safety instructions
H and P phrases	H: 302-311-410
	P: 280-301 + 312 + 330-302 + 352 + 312
MAK	Switzerland: 10 mg m −3 (measured as inhalable dust )
Toxicological data	1000 mg kg −1 ( LD 50 , rat , oral ) ; 970 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Temephos or Temefos is a chemical compound from the group of thiophosphoric acid esters .

Extraction and presentation

Temephos can be obtained by reacting 4,4'-thiodiphenol and dimethoxythiophosphonyl chloride.

properties

Temephos is a flammable colorless (white) solid that is practically insoluble in water. It hydrolyzes in strong bases and acids.

use

Temephos is used as an insecticide . It is used to combat mosquito and sand flies larvae in waters that are not used for drinking water . About £ 25,000 to £ 40,000 are used in the US each year. The effect is based on the inhibition of acetylcholinesterase .

Admission

Temephos is not permitted as an active ingredient in plant protection products in the European Union , so there are no plant protection products with this active ingredient on the market in Germany, Austria or Switzerland.

Web links

WHO: Chemical hazards in drinking-water: Temephos

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Entry on Temephos in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
↑ Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 3383-96-8 or Temephos ), accessed on November 2, 2015.
↑ meshb.nlm.nih.gov: Temefos , accessed January 14, 2019.
^ Entry on Temephos in the Hazardous Substances Data Bank , accessed on August 15, 2012.
↑ Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 335 ( limited preview in Google Book search).
↑ ^a ^b Terry R Roberts, David H Hutson, Philip W Lee, Peter H Nicholls: Metabolic Pathways of Agrochemicals: Part 2: Insecticides and Fungicides . Royal Society of Chemistry, 1999, ISBN 0-85404-499-X , pp. 491 ( limited preview in Google Book search).
↑ EPA: Temephos Facts (PDF; 13 kB), July 2001.
↑ Regulation (EC) No. 2076/2002 of the Commission of November 20, 2002 extending the deadline in accordance with Article 8 paragraph 2 of Council Directive 91/414 / EEC and on the non-inclusion of certain active substances in Annex I of this directive and the revocation of Approvals of plant protection products with these active ingredients (PDF) .
↑ General Directorate Health and Food Safety of the European Commission: Entry on Temephos in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved February 25, 2016.

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l Entry on Temephos in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .

[2] Swiss Accident Insurance Fund (Suva): Limit values - current MAK and BAT values (search for 3383-96-8 or Temephos ), accessed on November 2, 2015.

[3] shb.nlm.nih.gov: Temefos , accessed January 14, 2019.

[4] Entry on Temephos in the Hazardous Substances Data Bank , accessed on August 15, 2012.

[Thomas_A._Unger-5] Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 335 ( limited preview in Google Book search).

[Terry_R_Roberts,David_H_Hutson,Philip_W_Lee,Peter_H_Nicholls-6] Terry R Roberts, David H Hutson, Philip W Lee, Peter H Nicholls: Metabolic Pathways of Agrochemicals: Part 2: Insecticides and Fungicides . Royal Society of Chemistry, 1999, ISBN 0-85404-499-X , pp. 491 ( limited preview in Google Book search).

[EPA-7] EPA: Temephos Facts (PDF; 13 kB), July 2001.

[8] Regulation (EC) No. 2076/2002 of the Commission of November 20, 2002 extending the deadline in accordance with Article 8 paragraph 2 of Council Directive 91/414 / EEC and on the non-inclusion of certain active substances in Annex I of this directive and the revocation of Approvals of plant protection products with these active ingredients (PDF) .

[PSM-9] General Directorate Health and Food Safety of the European Commission: Entry on Temephos in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; Retrieved February 25, 2016.