According to the ICTV status of November 2018, the genus Teschovirus consists of a single species Teschovirus A , in which the previous 11 species are grouped together as subtypes. They are from non-enveloped viruses from the family Picornaviridae , which have been isolated from pigs . The generic name comes from the name of the disease caused, the Teschen disease in domestic and wild boar , which can lead to encephalomyelitis with paralysis; it is therefore also known as “infectious pig paralysis”. The symptoms and course are very similar to poliomyelitis in humans.
Originally, the teschoviruses were classified as members of the genus enterovirus and designated porcine enterovirus 1-13 ; However, due to their instability with regard to low pH values and sequence comparisons, they have also been grouped together in their own genus. The virus particles (virions) of the porcine teschoviruses are about 27 to 30 nm in diameter and go through a maturation cycle outside the host cell. The viruses of the genus teschovirus differ from other members of the Picornaviridae by a very short IRES 290 nt , even without binding of the initiation factor eIF-4G , the translation can initiate. The IRES of the teschoviruses has structure and sequence similarities with the IRES of the hepatitis C virus .
Systematics
As of November 2018, the genus Teschovirus is structured as follows:
'Porcines Teschovirus 14' to '16' ('PTV-14' bit 'PTV-16')
literature
G. Stanway, F. Brown et al .: Genus Teschovirus . In: CM Fauquet, MA Mayo et al .: Eighth Report of the International Committee on Taxonomy of Viruses , London, San Diego, 2004, p. 774
R. Zell, M. Dauber, A. Krumbholz et al .: Porcine teschoviruses comprise at least eleven distinct serotypes: molecular and evolutionary aspects . J. Virology (2001) 75: pp. 1620-1631 PMID 11160660
Y. Kaku, A. Sarai, Y. Murakami: Genetic reclassification of porcine enteroviruses . J Gen Virology (2001) 82 (Pt 2): pp. 417-424 PMID 11161281