Tiapride

from Wikipedia, the free encyclopedia
Structural formula
Structure of tiapride
General
Non-proprietary name Tiapride
other names

N -2- (diethylaminoethyl) -5-methylsulfonyl-2-methoxybenzamide

Molecular formula C 15 H 24 N 2 O 4 S
External identifiers / databases
CAS number
EC number 256-907-9
ECHA InfoCard 100.051.717
PubChem 5467
ChemSpider 5268
DrugBank DB13025
Wikidata Q416414
Drug information
ATC code

N05 AL03

Drug class

Antidopaminergic used to treat dyskinesia

properties
Molar mass 328.43 g mol −1
Melting point

123-125 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data

4840 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Tiapride (N-2- (diethylaminoethyl) -5-methylsulfonyl-2-methoxybenzamide) is an antihyperkinetic with a plasma half-life of 2.9 to 3.6 hours. It is one of the typical neuroleptics . In terms of its effect and structure, tiapride is very similar to sulpiride . The active ingredient is usually used as the hydrochloride .

Mode of action

Tiapride acts as an antagonist on dopamine receptors .

It is used for obsessive-compulsive movement disorders :

  • for the treatment of tics in Tourette's syndrome ,
  • in dyskinesias e.g. B. in chorea ,
  • and - although a neuroleptic itself - in the movement disorders caused by other neuroleptics, such as akathisia and dyskinesia (e.g. the "tripping" caused by haloperidol).
  • also tiapride can be used as an antiemetic used

It also plays a role in the treatment of alcohol withdrawal , and a weak antidepressant effect has been reported.

Trade names

Tiaprid is commercially available in Germany, Austria and Switzerland as a generic and in Austria under the name Delpral.

See also

Individual evidence

  1. ↑ a b c d Entry on tiapride. In: Römpp Online . Georg Thieme Verlag, accessed on January 29, 2019.
  2. ↑ a b c data sheet Tiapride hydrochloride from Sigma-Aldrich , accessed on June 16, 2011 ( PDF ).
  3. ^ Onmeda online health portal : Tiaprid ( Memento of March 9, 2009 in the Internet Archive ).