Tolazoline
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General | |||||||||||||
Non-proprietary name | Tolazoline | ||||||||||||
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Molecular formula | C 10 H 12 N 2 | ||||||||||||
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properties | |||||||||||||
Molar mass | 160.22 g mol −1 | ||||||||||||
Physical state |
firmly |
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Melting point |
66-69 ° C |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Tolazoline is a heterocyclic chemical compound that belongs to the group of imidazole or imidazoline derivatives. The fabric is a drug used, is there to the α 2 -adrenoceptor - antagonists or to the sympatholytic . At the same time the effect of is Xylazine and other α 2 - agonist canceled. Tolazoline is used intravenously in the treatment of circulatory disorders ( vasodilators , for example in the retina and in the Eisenmenger reaction ) and in veterinary medicine.
Clinical information
Application areas (indications)
There is no approval in Germany, Austria or Switzerland for the indicated indications.
- Vascular spasm of the central artery of the retina
- Agents used to treat cocaine overdoses
Individual evidence
- ↑ DrugBank: Tolazoline (DB00797)
- ↑ a b c d data sheet 2-Benzylimidazoline from Sigma-Aldrich , accessed on April 24, 2011 ( PDF ).
- ↑ a b c entry to Tolazolin at Vetpharm, accessed on 10 July 2011th
- ↑ W. Erhardt, J. Henke, J. Haberstroh: Anesthesia and analgesia in small and domestic animals as well as in birds, reptiles, amphibians and fish. Schattauer Verlag, 2004, ISBN 3-7945-2057-2 , p. 30.
- ↑ Cocaine overdose. ( Memento of the original from June 18, 2011 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Entry at thema-drogen.net.