Tolazoline

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Structural formula
Structural formula of tolazoline
General
Non-proprietary name Tolazoline
other names
  • 2- (Phenylmethyl) -4,5-dihydro-1 H -imidazole ( IUPAC )
  • 2-benzyl-2-imidazoline
Molecular formula C 10 H 12 N 2
External identifiers / databases
CAS number
PubChem 5504
DrugBank DB00797
Wikidata Q413772
Drug information
ATC code
Drug class

Sympatholytic

Mechanism of action
properties
Molar mass 160.22 g mol −1
Physical state

firmly

Melting point

66-69 ° C

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 302-312-315-319-332-335
P: 261-280-305 + 351 + 338
Toxicological data

350 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Tolazoline is a heterocyclic chemical compound that belongs to the group of imidazole or imidazoline derivatives. The fabric is a drug used, is there to the α 2 -adrenoceptor - antagonists or to the sympatholytic . At the same time the effect of is Xylazine and other α 2 - agonist canceled. Tolazoline is used intravenously in the treatment of circulatory disorders ( vasodilators , for example in the retina and in the Eisenmenger reaction ) and in veterinary medicine.

Clinical information

Application areas (indications)

There is no approval in Germany, Austria or Switzerland for the indicated indications.

  • Vascular spasm of the central artery of the retina
  • Agents used to treat cocaine overdoses

Individual evidence

  1. ↑ DrugBank: Tolazoline (DB00797)
  2. ↑ a b c d data sheet 2-Benzylimidazoline from Sigma-Aldrich , accessed on April 24, 2011 ( PDF ).
  3. ↑ a b c entry to Tolazolin at Vetpharm, accessed on 10 July 2011th
  4. ↑ W. Erhardt, J. Henke, J. Haberstroh: Anesthesia and analgesia in small and domestic animals as well as in birds, reptiles, amphibians and fish. Schattauer Verlag, 2004, ISBN 3-7945-2057-2 , p. 30.
  5. ↑ Cocaine overdose. ( Memento of the original from June 18, 2011 in the Internet Archive ) Info: The @1@ 2Template: Webachiv / IABot / www.thema-drogen.net archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Entry at thema-drogen.net.