Tribromoethanol
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| General | |||||||||||||||||||
| Surname | Tribromoethanol | ||||||||||||||||||
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| Molecular formula | Br 3 CCH 2 OH | ||||||||||||||||||
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| Molar mass | 282.76 g mol −1 | ||||||||||||||||||
| Physical state |
firmly |
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| Melting point |
73-79 ° C |
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| boiling point |
92-93 ° C / 10 mmHg |
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||||||||
Tribromoethanol is a chemical compound from the group of alcohols . It is used in veterinary medicine as a sedative for intraperitoneal injection anesthesia of rodents .
synthesis
2,2,2-tribromoethanol is by reaction of aluminum ethoxide and elemental prepared bromine.
Applications
Tribromoethanol is used as a concentrate in a mass concentration of 55% in tertiary amyl alcohol under the name Avertin for injection anesthesia; this is applied as a 1.2–2.5% solution in physiological saline solution . Alternatively, tribromoethanol with buprenorphine or ketamine with xylazine are used. While the toxicity is low and the therapeutic index is large, the narcotic effect has been described as variable.
Individual evidence
- ↑ a b c d e f data sheet 2,2,2-tribromoethanol, 97% from Sigma-Aldrich , accessed on April 2, 2017 ( PDF ).
- ↑ Tribromoethanol (Avertin) . In: Cold Spring Harbor Protocols . Cold Spring Harbor Laboratory .
- ^ RE Meyer, RE Fish: A review of tribromoethanol anesthesia for production of genetically engineered mice and rats. In: Lab animal. Volume 34, Number 10, November 2005, pp. 47-52, doi : 10.1038 / laban1105-47 , PMID 16261153 .
- ^ A. Kar: "Medicinal Chemistry", Verlag New Age International, 2005, p. 66, ISBN 9788122415650 . ( limited preview in Google Book search).
- ↑ Butzengeiger, F. & Jüttemann, A. (2017): On the history of the narcotic Avertin introduced in 1927 . Anesthesia Intensivmed; 58: 268-273
- ↑ Guidelines for the Use of Tribromoethanol / Avertin Anesthesia . National Cancer Institute .
- ^ J. Weiss, F. Zimmermann: Tribromoethanol (Avertin) as an anaesthetic in mice. In: Laboratory animals. Volume 33, Number 2, April 1999, pp. 192-193, doi : 10.1258 / 002367799780578417 , PMID 10780824 .
- ^ WA Hill, JT Tubbs, CL Carter, JA Czarra, KM Newkirk, TE Sparer, B. Rohrbach, CM Egger: Repeated administration of tribromoethanol in C57BL / 6NHsd mice. In: Journal of the American Association for Laboratory Animal Science: JAALAS. Volume 52, Number 2, March 2013, pp. 176-179, PMID 23562101 , PMC 3624786 (free full text).